Anti-scratching behavioral effect of the essential oil and phytol isolated from Artemisia princeps Pamp. in mice

Planta medica
Kwon-Ryeol RyuDong-Hyun Kim

Abstract

The anti-scratching behavioral effect of the essential oil and phytol isolated from Artemisia princeps Pamp. (AP, family Asteraceae), which is widely used in traditional medicine for inflammatory diseases, was investigated IN VIVO. Treatment of mice with AP essential oil (APEO) and phytol inhibited histamine- and compound 48/80-induced scratching behaviors. The anti-scratching behavioral effects of APEO and phytol are in proportion to their vascular permeability-inhibitory effects. These agents also inhibited the level of allergic cytokines, IL-4, and TNF- α, and the activation of transcription factors, NF- κB and c-jun (AP-1), in histamine-treated skin tissues. Based on these results, APEO and phytol may improve scratching behavior in skin by inhibiting the expression of allergic cytokines via the regulation of NF- κB and AP-1 activation.

Citations

Jan 7, 2014·PLoS Neglected Tropical Diseases·Josué de MoraesPedro L S Pinto
Aug 3, 2012·Journal of Ethnopharmacology·Se-Eun JangDong-Hyun Kim
Apr 23, 2016·The Journal of Nutrition, Health & Aging·H-J ChoY-K Park
Sep 24, 2016·The Korean Journal of Parasitology·Maysa Ahmad ErakyGehan Abd El-Rahman Rashed
Dec 21, 2017·Frontiers in Cellular and Infection Microbiology·Ramanathan SrinivasanArumugam Veera Ravi
Feb 20, 2019·Inflammopharmacology·Muhammad Torequl Islam

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