PMID: 6965702Mar 1, 1980Paper

Anti-self receptors. I. Direct detection of H-2L region-restricted receptors on murine thymocytes

The Journal of Experimental Medicine
D Y Sia, C R Parish

Abstract

A high proportion (20--50%) of murine thymocytes form rosettes with either syngeneic or allogeneic erythrocytes. The specificity of this interaction was investigated by measuring the ability of different erythrocyte sonicates to inhibit rosette formation. With erythrocyte sonicates from recombinant mouse strains it was demonstrated that rosetting with syngeneic erythrocytes was mediated by H-2L and/or H-2D region-restricted receptors. The specificity of autorosetting was directly mapped to the H-2L region by the inability of erythrocyte sonicates from the BALB/c-H-2dm2 mutant, an H-2L-deletion mutant, to inhibit the rosetting of wild-type (BALB/c) thymocytes. The B10,2D2-H-2dm1 mutant, which has substantially modified H-2L and H-2D antigens, supported this conclusion. Furthermore, anti-H-2L sera were able to specifically block the inhibition of rosetting by erythrocyte sonicates. The above procedures clearly implicated the H-2L region in the thymocyte rosetting of d and k haplotypes. With the s haplotype the rosetting receptor was mapped to the H-2L/H-2D region, whereas with the b and q haplotypes rosetting was only mapped to the D end of the H-2 complex. This study also suggested complete cross-reaction between the thymocyte r...Continue Reading

References

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Citations

Jan 1, 1983·Immunogenetics·P M HogarthI F McKenzie
Dec 1, 1984·Cellular Immunology·I StefasB Serrou
Dec 30, 1982·Journal of Immunological Methods·C R ParishT J Higgins
Oct 1, 1981·European Journal of Biochemistry·D B RylattC R Parish
Jun 1, 1981·Immunology Today·C R ParishT J Higgins
Sep 1, 1981·Immunology Today·C R ParishD B Rylatt
Apr 29, 1982·Biochemical and Biophysical Research Communications·H Kolb
Feb 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E A Zherbin, A B Chukhlovin
Mar 1, 1987·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E A BorisovaK P Hanson

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