PMID: 6971253Mar 1, 1981Paper

Anti-self receptors. IV. H-2-restricted receptors on thymocytes recognize carbohydrate structures on target cells

Immunogenetics
D Y Sia, C R Parish

Abstract

Rosetting between thymocytes and autologous erythrocytes in mediated by receptors on thymocytes that primarily recognize self H-2L molecules on erythrocytes. This paper describes preliminary attempts to chemically characterize the receptor and acceptor molecules involved in this H-2-restricted interaction. On the basis of sugar inhibition studies and the sensitivity of the receptors to protease and glycosidase treatments it appears that a protein receptor on thymocytes recognizes the carbohydrate portion of a glycoprotein on erythrocytes. Furthermore, the thymocyte receptor appears to recognize terminal D-galactose, D-mannose and sialic acid residues on a branched-chain carbohydrate structure on erythrocytes, with mouse strains of different H-2 haplotype expressing carbohydrate structures that differ in the linkage of these three terminal sugars. These findings indicate that H-2-restricted carbohydrate-protein interactions can occur between cells, a conclusion with important theoretical implications.

References

Apr 1, 1977·The Journal of Experimental Medicine·I F McKenzieC R Parish
Jun 1, 1979·The Journal of Experimental Medicine·D PrimiJ W Goodman
Aug 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J Charreire, J F Bach
Mar 1, 1980·The Journal of Experimental Medicine·D Y Sia, C R Parish

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Citations

Jan 1, 1993·Folia Microbiologica·J KubrychtM Pospísil
Jan 1, 1985·Cancer Metastasis Reviews·C L Reading, J T Hutchins
Jan 1, 1997·Critical Reviews in Biotechnology·J Kubrycht, K Sigler
Apr 29, 1982·Biochemical and Biophysical Research Communications·H Kolb

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