Anti-sickling Activity of Ursolic Acid Isolated from the Leaves of Ocimum gratissimum L. (Lamiaceae)

Natural Products and Bioprospecting
Dorothée Dinangayi TshilandaPius Tshimankinda Mpiana

Abstract

The present study reports in vitro anti-sickling activity and phytochemical analyses of the leaves of Ocimum gratissimum. Biological testing revealed that the plant extracts possess antisickling effects. The combination of spectroscopic techniques: 1D-NMR, 2D-NMR and MS revealed that ursolic acid is the major biologically active compound of O. gratissimum (Silva et al. in Molecules 13:2482-2487, 2008; Kedar et al. J Food Drug Anal 20:865-871, 2012). This study is the first report of the antisickling activity of ursolic acid isolated from O. gratissimum. The pharmaceutical relevance of findings from this study derives from the possibility of integrating O. gratissimum as an antisickling plant in the pharmacopoeia of Democratic Republic of the Congo. The identification of the active principle could enhance the standardization of antisickling recipe.

References

Jan 24, 2002·Journal of Agricultural and Food Chemistry·Shengmin SangChi-Tang Ho
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Mar 8, 2007·Evidence-based Complementary and Alternative Medicine : ECAM·Firouz Matloubi MoghaddamGholamreza Amin
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Citations

Nov 17, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Jules Munganga KitadiPius Tshimankinda Mpiana
Mar 7, 2021·International Journal of Molecular Sciences·Coralia CotoraciAnca Hermenean
Nov 4, 2021·BMC Complementary Medicine and Therapies·Quadri K AlabiDeborah Kajewole-Alabi

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Methods Mentioned

BETA
NMR
column chromatography
electrophoresis

Software Mentioned

MOTIC Images 2000

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