Anti-staphylococcal activity of indolmycin, a potential topical agent for control of staphylococcal infections

The Journal of Antimicrobial Chemotherapy
Julian Gregston HurdleIan Chopra

Abstract

We sought to investigate the anti-staphylococcal activity of indolmycin, with particular emphasis on comparing its activity with fusidic acid and mupirocin. Established procedures were used to examine the activity of indolmycin against a range of clinical isolates, including strains resistant to fusidic acid and mupirocin. Indolmycin-resistant mutants were recovered and characterized phenotypically and genotypically. Indolmycin was bacteriostatic and demonstrated good activity against MSSA (methicillin-susceptible Staphylococcus aureus), MRSA (methicillin-resistant S. aureus) and VISA (vancomycin-intermediate S. aureus), including strains resistant to mupirocin or fusidic acid. Spontaneous indolmycin-resistant mutants occurred at a lower frequency than those selected by mupirocin or fusidic acid and exhibited no cross-resistance with the comparative drugs. High-level resistance (indolmycin MIC 128 mg/L) that was associated with an H43N mutation in tryptophanyl-tRNA synthetase (TrpS), the target enzyme of indolmycin, resulted in loss of bacterial fitness. However, the locus responsible for low-level indolmycin resistance (indolmycin MICs 8-32 mg/L) was not identified. Indolmycin is a potent anti-staphylococcal agent, which exhib...Continue Reading

Citations

Nov 13, 2004·Current Infectious Disease Reports·Philip M Polgreen, Loreen A Herwaldt
Sep 6, 2011·Nature Chemical Biology·Hao WangTimothy C Meredith
Jun 24, 2009·Antimicrobial Agents and Chemotherapy·James J Vecchione, Jason K Sello
Sep 29, 2005·Antimicrobial Agents and Chemotherapy·Urs A OchsnerIan A Critchley
Nov 24, 2005·Antimicrobial Agents and Chemotherapy·Julian Gregston HurdleIan Chopra
Jul 29, 2005·Antimicrobial Agents and Chemotherapy·Elisabeth KugelbergDiarmaid Hughes
Jan 25, 2014·Organic & Biomolecular Chemistry·Fabien PlissonRobert J Capon
Nov 20, 2012·Future Medicinal Chemistry·Shivaputra A PatilDuane D Miller
Apr 28, 2007·Expert Opinion on Investigational Drugs·Urs A OchsnerNebojsa Janjic
Mar 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yi-Ling DuKatherine S Ryan
Nov 6, 2008·Dermatologic Clinics·Dirk M Elston
Oct 16, 2012·Expert Opinion on Therapeutic Patents·Bharat Gadakh, Arthur Van Aerschot
Oct 13, 2005·Expert Opinion on Pharmacotherapy·Michael J Sladden, Graham A Johnston
Apr 28, 2011·FEMS Microbiology Reviews·Cheryl P AndamJohann Peter Gogarten
Dec 4, 2014·The Journal of Antibiotics·Justin I MontgomeryAlita A Miller
Oct 5, 2011·European Journal of Medicinal Chemistry·Gaston H M Vondenhoff, Arthur Van Aerschot
Jun 10, 2016·Scientific Reports·Charisse Flerida A PasajeStuart A Ralph
Oct 27, 2016·Methods : a Companion to Methods in Enzymology·Eric A First, Charles J Richardson
Dec 26, 2016·Biochemical Pharmacology·Savannah Colameco, Marie A Elliot
Apr 17, 2017·European Journal of Medicinal Chemistry·Navriti Chadha, Om Silakari
Sep 9, 2011·The Cochrane Database of Systematic Reviews·Peter BowerNancy Rowland
Oct 10, 2006·International Journal of Immunopathology and Pharmacology·A M FerriniB Oliva
Nov 12, 2015·The Journal of Biological Chemistry·Tishan L WilliamsCharles W Carter
Aug 14, 2019·Nature Chemical Biology·Yi-Ling DuKatherine S Ryan
Jul 4, 2007·The Journal of Antimicrobial Chemotherapy·Yang WuHualiang Jiang
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Djenisa H A RochaArtur M S Silva
Jan 9, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abdelaziz TouatiAssia Mairi
Dec 14, 2006·ACS Chemical Biology·Sandro F Ataide, Michael Ibba
Apr 13, 2021·ACS Infectious Diseases·Palak BabbarD Srinivasa Reddy
Dec 5, 2008·Journal of Combinatorial Chemistry·Carmen Gil, Stefan Bräse

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