Anti-steatotic and anti-inflammatory roles of syringic acid in high-fat diet-induced obese mice

Food & Function
Ju Ri HamMi-Kyung Lee

Abstract

This study examined the effects of syringic acid (SA) on obese diet-induced hepatic dysfunction. Mice were fed high-fat diet (HFD) with or without SA (0.05%, wt/wt) for 16 weeks. SA reduced the body weight, visceral fat mass, serum levels of leptin, TNFα, IFNγ, IL-6 and MCP-1, insulin resistance, hepatic lipid content, droplets and early fibrosis, whereas it elevated the circulation of adiponectin. SA down-regulated lipogenic genes (Cidea, Pparγ, Srebp-1c, Srebp-2, Hmgcr, Fasn) and inflammatory genes (Tlr4, Myd88, NF-κB, Tnfα, Il6), whereas it up-regulated fatty acid oxidation genes (Pparα, Acsl, Cpt1, Cpt2) in the liver. SA also decreased hepatic lipogenic enzyme activities and elevated fatty acid oxidation enzyme activities relative to the HFD group. These findings suggested that dietary SA possesses anti-obesity, anti-inflammatory and anti-steatotic effects via the regulation of lipid metabolic and inflammatory genes. SA is likely to be a new natural therapeutic agent for obesity or non-alcoholic liver disease.

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Citations

Mar 30, 2019·Human & Experimental Toxicology·S Gheena, D Ezhilarasan
Mar 11, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ju Ri HamMi-Kyung Lee
Oct 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ferdaous AlbouchiVenera Cardile
Feb 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Noor Atiqah Aizan Abdul KadirIntan Safinar Ismail
Dec 4, 2020·International Journal of Molecular Sciences·Eri AdamsRyoung Shin
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Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Salman AhmedSeema Patel

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