Anti-streptokinase titers and response to streptokinase treatment in Pakistani patients

International Journal of Cardiology
Khawar A KazmiNaseema Mehboobali

Abstract

In order to investigate whether anti-streptokinase (anti-SK) antibody titers have any effect on response to standard dose (1.5 million units) streptokinase (SK) therapy in patients with acute myocardial infarction, anti-SK titers in plasma were determined in 97 such patients. These patients were classified as "responders" or "non-responders" on the basis of a criteria which involved resolution of chest pain in less than 90 min after the start of thrombolysis, greater than 50% reduction of ST segment elevation in two contiguous leads showing maximum elevations in a 12-lead tracing, reperfusion arrythmias and slope of increase in creatine kinase over a 90-min period after initiation of thrombolysis. Anti-SK antibody levels in plasma were determined in these patients as well as in 50 normal healthy subjects by dissolution of clot method. Mean+/-S.D. anti-SK levels among responders, non-responders and normal healthy subjects were found to be 0.21+/-0.12, 0.25+/-0.22 and 0.21+/-0.15 million units, respectively. A comparison of these mean values by one-way ANOVA revealed no statistical difference (P=0.68). However, when compared with the reported values for a Western population, these values were found to be significantly higher (P<0...Continue Reading

References

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Citations

Nov 18, 2006·Journal of Thrombosis and Thrombolysis·Adinarayana KunamneniPoluri Ellaiah
Dec 31, 2003·Biotechnology Advances·Anirban BanerjeeU C Banerjee
Oct 20, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Mojgan BandehpourBahram Kazemi

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