Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial

Nutrients
D J WhiteAndrew B Scholey

Abstract

L-theanine (γ-glutamylethylamide) is an amino acid found primarily in the green tea plant. This study explored the effects of an L-theanine-based nutrient drink on mood responses to a cognitive stressor. Additional measures included an assessment of cognitive performance and resting state alpha oscillatory activity using magnetoencephalography (MEG). Thirty-four healthy adults aged 18-40 participated in this double-blind, placebo-controlled, balanced crossover study. The primary outcome measure, subjective stress response to a multitasking cognitive stressor, was significantly reduced one hour after administration of the L-theanine drink when compared to placebo. The salivary cortisol response to the stressor was reduced three hours post-dose following active treatment. No treatment-related cognitive performance changes were observed. Resting state alpha oscillatory activity was significantly greater in posterior MEG sensors after active treatment compared to placebo two hours post-dose; however, this effect was only apparent for those higher in trait anxiety. This change in resting state alpha oscillatory activity was not correlated with the change in subjective stress response or the cortisol response, suggesting further rese...Continue Reading

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Citations

Dec 12, 2017·The Proceedings of the Nutrition Society·Andrew Scholey
Dec 6, 2017·Journal of Clinical Biochemistry and Nutrition·Keiko UnnoYoriyuki Nakamura
Dec 27, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A B Katasonov
Feb 8, 2019·Nature·Natasha Gilbert
Aug 15, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Filipe Lopes SakamotoHeitor Oliveira Santos
Nov 5, 2020·Poultry Science·Muhammad SaeedSun Chao
Sep 25, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad SaeedChao Sun
Mar 6, 2021·Frontiers in Nutrition·Josep Bassaganya-RieraMauro Serafini

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

MaxFilter
Brainstorm
MATLAB

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