Anti-stress effects of 20(S)-protopanaxadiol and 20(S)-protopanaxatriol in immobilized mice

Biological & Pharmaceutical Bulletin
Hyun A OhDong-Hyun Kim

Abstract

Panax ginseng C.A. MEYER (Araliaceae), which contains ginsenosides as its main components, has been shown to have various biological effects, including anti-inflammatory, anxiolytic, anti-stress, and anti-tumor effects. Orally administered ginsenoside Rb1 and Re are metabolized to 20(S)-protopanaxadiol (PPD) and compound K via ginsenoside Rd and 20(S)-protopanaxatriol (PPT) and ginsenoside Rh1 via ginsenoside Rg1 by gut microbiota, respectively. Therefore, we investigated the anti-stress effects of these metabolites, PPD and PPT, by measuring their anxiolytic and anti-inflammatory effects in immobilized mice. Treatment with PPD and PPT prior to immobilization stress increased the time spent in open arms and open arm entries in the elevated plus-maze (EPM) test. The anxiolytic effects of PPD (10 mg/kg) and PPT (10 mg/kg) were comparable to that of buspirone (1 mg/kg). This observed anxiolytic effect of PPD was significantly blocked by flumazenil or bicuculline, and the effect of PPT was blocked by WAY-100635. Treatment with PPD also potently suppressed immobilization stress-induced serum levels of corticosterone and interleukin (IL)-6 by the enzyme-linked immunosorbent assay. However, PPT treatment did not suppress them. Based o...Continue Reading

References

Sep 14, 1999·Circulation·D G BendittN Samniah
Nov 19, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·James D ChurchillRichard A Deyo
Nov 26, 2002·Journal of Neuroimmunology·John J HaddadBared Safieh-Garabedian
Jul 17, 2003·Planta medica·Min-Kyung ChooDong-Hyun Kim
Aug 12, 2003·Trends in Immunology·David A Padgett, Ronald Glaser
Jan 23, 2004·Journal of Pharmacological Sciences·Deepak RaiGautam Palit
Jul 9, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jeong-Hill ParkKi-Wan Oh
Sep 6, 2005·Biological & Pharmaceutical Bulletin·Hwa-Young ChaKi-Wan Oh
Oct 29, 2005·Journal of Neuroimmunology·Atsuo SekiyamaHaruki Okamura
Jan 18, 2006·European Journal of Pharmacology·Mellisa N CarrHiroyuki Yoshimura
Mar 15, 2006·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sang Hee LeeBong Chul Chung
Nov 15, 2006·Journal of Ethnopharmacology·Oliver GrundmannVeronika Butterweck
Dec 19, 2006·Stress : the International Journal on the Biology of Stress·Eiki SatohYoshitaka Omata
May 22, 2007·Pharmacology, Biochemistry, and Behavior·Hyun-Sook YuChoon-Gon Jang
Nov 24, 2007·Journal of Agricultural and Food Chemistry·Gi Cheol HanSung Hyun Chung
Jun 7, 2008·Neuroscience and Biobehavioral Reviews·Laurence LanfumeyMichel Hamon
Feb 24, 2009·Journal of Neuroimmunology·Jin-Sun ParkHee-Sun Kim
Jun 11, 2011·Behavioral Medicine·Na-Hyung KimHyung-Min Kim
Sep 29, 2011·Nature Reviews. Endocrinology·Andrew S Papadopoulos, Anthony J Cleare
Apr 5, 2012·Nature Reviews. Cardiology·Andrew Steptoe, Mika Kivimäki
Jan 1, 2012·Journal of Ginseng Research·Dong-Hyun Kim

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Citations

Oct 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yiqiong PuTong Zhang
Jan 14, 2020·Stress : the International Journal on the Biology of Stress·Karla De Michelis MograbiClement Hamani
Jan 12, 2019·The American Journal of Chinese Medicine·Wonhwa LeeJong-Sup Bae
Apr 24, 2020·Frontiers in Neuroscience·Shawn D FlanaganWilliam J Kraemer
Apr 21, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weijie XieXiaobo Sun

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