Anti-T-cell antibodies for the treatment of acute rejection after renal transplantation

Expert Opinion on Biological Therapy
Martijn W F van den HoogenLuuk B Hilbrands

Abstract

Given the central role of T cells in the alloimmune response, anti-T-cell antibodies retain a prominent place in the treatment of renal allograft rejection. During the past decades, many anti-T-cell antibodies have emerged and subsequently left the field of solid organ transplantation, but rabbit-antithymocyte globulin (ATG) and the humanized anti-CD52 monoclonal rat antibody alemtuzumab have remained. This article reviews the literature about the use of ATG and alemtuzumab for the treatment of acute rejection after renal transplantation. Furthermore, it discusses possible side effects, including infusion reactions. A literature search using PubMed and Embase databases was undertaken using search words alemtuzumab, antithymocyte globulin, rejection, kidney and renal transplantation. Treatment of severe or steroid-resistant renal allograft rejections with ATG is very effective, but is also associated with frequent infusion reactions and an increased incidence of infections and posttransplant lymphoproliferative disease. Alemtuzumab may prove to be an attractive alternative. It can be administered easily, is relatively cheap and nearly devoid of acute side effects, but the long-term efficacy and safety as anti-rejection treatment...Continue Reading

References

Dec 1, 1979·Transplantation·C F ShieldP S Russell
Dec 2, 1988·JAMA : the Journal of the American Medical Association·L BieloryM A Kaliner
Nov 14, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C Prin MathieuG C Faure
Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Oct 30, 2001·Transplant Immunology·J F ReganUNKNOWN US Thymoglobulin Multi-Center Study Group
Aug 16, 2002·Medical Oncology·Kanti Rai, Michael Hallek
Jun 7, 2003·Drugs·James E Frampton, Antona J Wagstaff
Aug 27, 2003·Seminars in Oncology·Neus VillamorDolors Colomer
Dec 18, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Rami T BustamiFriedrich K Port
Nov 2, 2004·Clinical Transplantation·Philip G ThomasKristene K Gugliuzza
Dec 24, 2004·The New England Journal of Medicine·Philip F Halloran
Apr 26, 2005·Transplantation Proceedings·A BasuR Shapiro
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Dixon B KaufmanFrank P Stuart
Jan 20, 2006·Transplantation·Debra D BloomStuart J Knechtle
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D KirkR B Mannon
Aug 18, 2006·Journal of the American Society of Nephrology : JASN·Marta LopezNader Najafian
Dec 14, 2006·Transplantation·Martin S Zand
Dec 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anton Y PelegDavid L Paterson
Sep 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D KirkH M Kauffman
Dec 21, 2007·The New England Journal of Medicine·Henrik EkbergUNKNOWN ELITE-Symphony Study
Jan 1, 2008·Transplantation·Menna R ClatworthyChristopher J E Watson
Feb 12, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D D BloomS J Knechtle
May 31, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R MargreiterR Y Calne
Jul 29, 2008·Current Opinion in Organ Transplantation·Olivier Thaunat, Antonino Nicoletti
Aug 21, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Christian TosoColin C Anderson
Oct 3, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F Vincenti, A D Kirk
Oct 3, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A S R MuthusamyP J Friend
Dec 3, 2008·The Journal of Experimental Medicine·Xueli YuanM Javeed Ansari
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
May 16, 2009·Current Opinion in Organ Transplantation·Miranda Dierselhuis, Els Goulmy
Oct 8, 2009·Nature Reviews. Immunology·Jeffrey A BluestoneBrigitta Stockinger

❮ Previous
Next ❯

Citations

Oct 7, 2015·Journal of the Neurological Sciences·Mojtaba FarjamAbdolmohamad Rostami
Nov 22, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M W F van den HoogenL B Hilbrands
Mar 13, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G I SnellUNKNOWN ATG Study Investigators
Aug 9, 2016·Transplantation Direct·Anne P BouvyCarla C Baan
Jan 28, 2017·Immunotherapy·Alexander E Giakoustidis, Dimitrios E Giakoustidis
Jul 3, 2017·Clinical Pharmacokinetics·Marieke van der ZwanDennis A Hesselink
Mar 3, 2015·Allergy & Rhinology·Stephanie A WolaninEric A Meier
Mar 31, 2021·Journal of Critical Care·M W F van den HoogenD A Hesselink

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Martijn W F van den HoogenL B Hilbrands
Immunotherapy
Martijn W F van den Hoogen, Luuk B Hilbrands
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Donald E Hricik
Transplant International : Official Journal of the European Society for Organ Transplantation
Alexander KainzRainer Oberbauer
© 2021 Meta ULC. All rights reserved