Anti-telomere antibodies in systemic lupus erythematosus (SLE): a comparison with five antinuclear antibody assays in 430 patients with SLE and other rheumatic diseases

Annals of the Rheumatic Diseases
E M SalonenH Julkunen

Abstract

To investigate the prevalence and diagnostic significance of antibodies against telomeric DNA in systemic lupus erythematosus (SLE) and other autoimmune rheumatic diseases, and to make comparisons with five conventional anti-DNA or anti-nuclear antibody (ANA) assays. Antibodies to telomeres, which are highly repetitive sequences of DNA (TTAGGG/CCCTAA) at the end of eukaryotic chromosomes, were measured by an enzyme linked immunosorbent assay (ELISA) in 305 patients with SLE and 125 patients with other autoimmune rheumatic diseases (78 rheumatoid arthritis, 32 primary Sjögren's syndrome, eight mixed connective tissue disease, seven miscellaneous rheumatic diseases). Other assays used were two commercial ELISA assays for anti-dsDNA using calf thymus as antigen, Crithidialuciliae immunofluorescence, and radioimmunoassay (RIA) for anti-dsDNA and immunofluorescence using Hep-2 cells for ANA. The prevalence of anti-telomere in SLE was 60%, v 5% in rheumatoid arthritis and 18% in other autoimmune rheumatic diseases. Specificity of anti-telomere for SLE was 91%; positive and negative predictive values were 95% and 46%, respectively. For anti-dsDNA by two ELISA assays using calf thymus as antigen, sensitivities were 69% and 29% and spec...Continue Reading

References

Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jan 1, 1993·Nihon rinsho. Japanese journal of clinical medicine·K NagaokaS Ozaki
Jul 27, 2000·Journal of Clinical Pathology·W Egner

❮ Previous
Next ❯

Citations

Apr 22, 2004·QJM : Monthly Journal of the Association of Physicians·L S CrossS A Misbah
May 16, 2006·Autoimmunity·Antonella Radice, Renato Alberto Sinico
May 20, 2005·Rheumatology·G Riemekasten, B H Hahn
Aug 13, 2005·Scandinavian Journal of Rheumatology·H JulkunenA Miettinen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.