PMID: 3321372Oct 1, 1987Paper

Anti-tetanus immunization. Complexity and polymorphism of humoral and cellular manifestations

Revue française de transfusion et immuno-hématologie
E Eyquem, J de Saint Martin

Abstract

In general, anti-tetanus vaccination is well tolerated by the recipients, but the repeated inoculations of the vaccine might result in immediate or delayed type of hypersensitivity. The more recent knowledge of the epitopic construction of the toxin defined by tools offered by molecular biology, has helped understand the complexity of humoral and cellular responses as a consequence to vaccination. We have analyzed in this work major antitetanus post-vaccinal manifestations in normal subjects, as well as in patients suffering from different pathological disorders, with regard to immunoglobulin class expression, idiotypic profile, HLA-susceptibility and in vitro cellular responses.

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.