PMID: 15389121Sep 25, 2004Paper

Anti-thrombomodulin antibodies and venous thrombosis

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Sami GuermaziKoussay Dellagi

Abstract

Thrombomodulin (TM) is a cell surface endothelial glycoprotein having anticoagulant properties. It inhibits thrombin, and activates protein C, leading to the inhibition of activated factors V and VIII. TM autoantibodies could theoretically predispose to thrombosis. We have tested 83 unselected patients with deep venous thrombosis, 36 males and 47 females aged from 1 to 70 years [mean +/- standard deviation (SD), 34.2 +/- 14.5 years] for the presence of IgG anti-TM in their plasmas. Tests were performed by enzyme-linked immunosorbent assay (ELISA) using recombinant human TM kindly provided by PAION GmbH (Aachen, Germany). Results are expressed as the optical density (OD) differences between coated and un-coated wells. Plasmas from 83 normal volunteer donors were used to define the cut-off value as the mean of absorbance of the control group + 3 SDs. The median OD of normal controls group was 0.024 (mean, 0.034; SD, 0.066; range, -0.048 to 0.309). The median OD obtained with plasmas from patients was 0.048 (mean, 0.114; SD, 0.215; range, -0.039 to 1.312) and was significantly higher than that of the control group (P < 0.0001). Choosing a cut-off value of 0.232 (mean OD of the control group + 3 SDs), 11 patients are considered as ...Continue Reading

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Citations

Sep 26, 2008·Cell and Tissue Research·Eric SimoneVladimir Muzykantov
Apr 9, 2008·La Revue de médecine interne·J Emmerich
Oct 6, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vladimir V ShuvaevVladimir R Muzykantov
Jul 15, 2005·Annals of the New York Academy of Sciences·Wolfgang MiesbachInge Scharrer
Jul 1, 2009·American Journal of Hematology·Valeria RossettoPaolo Simioni

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