Anti-Thrombotic Strategies in Elderly Patients Receiving Platelet Inhibitors

European Heart Journal. Cardiovascular Pharmacotherapy
Andreas SchäferJ Bauersachs

Abstract

Acetyl-salicylic acid (ASA) is the basic anti-thrombotic therapy used for single anti-platelet therapy (SAPT) in primary as well as secondary prevention of atherosclerotic disease. Dual anti-platelet therapy (DAPT) is the cornerstone of maintenance medication following elective percutaneous coronary intervention or acute coronary syndromes (ST elevation myocardial infarction, non-ST elevation myocardial infarction, unstable angina). DAPT duration has been frequently discussed. Currently, guideline recommendations strengthen the importance of individualised treatment to reduce bleeding risk based on clinical predictors, of which older age is an important one. Patients aged ≥75 years are often underrepresented in randomised clinical trials, but present a patient cohort deemed both at heightened ischaemic as well as bleeding risk. We aimed to summarise the evidence or the lack of evidence for anti-platelet treatment strategies in patients aged ≥75 years including combinations with anticoagulants in secondary prevention or coronary interventions in elderly patients with atrial fibrillation. This review article represents the authors interpretation of available data and is not discussed by a formal task force; it is intended to poin...Continue Reading

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Citations

Sep 11, 2019·European Heart Journal. Cardiovascular Pharmacotherapy·Ourania S Kotsiou, Ioannis K Xirogiannis
May 1, 2020·Cardiovascular Drugs and Therapy·Andreas SchäferJohann Bauersachs
Sep 10, 2019·European Heart Journal. Cardiovascular Pharmacotherapy·Andreas SchäferJohann Bauersachs
Oct 19, 2020·Thrombosis and Haemostasis·James D McFadyen, Karlheinz Peter

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