Anti-thymocyte globulin for conditioning in matched unrelated donor hematopoietic cell transplantation provides comparable outcomes to matched related donor recipients.

Bone Marrow Transplantation
D A PortierAmir A Toor

Abstract

Rabbit anti-thymocyte globulin (ATG) is used as prophylaxis against GVHD following allogeneic hematopoietic cell transplantation (HCT). At our institution, ATG is exclusively used in the conditioning of matched unrelated donor (URD) transplant recipients. A total of 50 URD HCT recipients who received ATG (ATG group) were retrospectively compared with 48 matched related donor (MRD) HCT recipients who did not receive ATG (no ATG group). There were no significant differences between the groups in rates of day 100 mortality, acute GVHD or relapse. Chronic GVHD incidence was significantly lower in the ATG group (P = 0.007). At a median follow-up of 36 months in the entire cohort, 50% patients are alive in the ATG group and 63% of the patients are alive in the no ATG group (P = 0.13). We conclude that the administration of ATG to patients undergoing URD HCT preserves the anti-leukemia benefit of the transplant, while reducing the risk of developing GVHD, resulting in OS rates that are comparable to MRD HCT recipients.

References

Oct 30, 2001·Transplant Immunology·J F ReganUNKNOWN US Thymoglobulin Multi-Center Study Group
Nov 7, 2002·Bone Marrow Transplantation·P DugganUNKNOWN Alberta Blood and Bone Marrow Transplant Program
Jul 19, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Edmund K WallerIstvan Redei
Sep 25, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael BoeckhJohn Zaia
Mar 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frédéric BaronRainer Storb
Sep 30, 2005·The New England Journal of Medicine·Robert LowskySamuel Strober
Apr 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Andrea BacigalupoUNKNOWN Gruppo Italiano Trapianti Midollo Osseo (GITMO)
Apr 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·H Joachim DeegRainer Storb
Aug 18, 2006·Journal of the American Society of Nephrology : JASN·Marta LopezNader Najafian
Feb 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·James A RussellDouglas Stewart
Mar 24, 2007·PLoS Medicine·Effie W PetersdorfZhen Guo
May 3, 2008·The New England Journal of Medicine·Richard F SchlenkUNKNOWN German-Austrian Acute Myeloid Leukemia Study Group
Jul 22, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Francis AyukAxel R Zander
Aug 30, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christopher N BredesonDouglas A Stewart
Sep 24, 2008·Blood·Michi KameiYoshiki Akatsuka
Oct 3, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SternA Gratwohl
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mukta AroraEffie W Petersdorf
Jul 3, 2009·Bioinformatics·David S DeLucaRainer Blasczyk
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mehdi HamadaniSteven M Devine
Oct 14, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel J WeisdorfUNKNOWN Chronic Leukemia Working Committee
Mar 26, 2010·Blood·Satoko MorishimaUNKNOWN Japan Marrow Donor Program
Jul 14, 2010·Transplantation Proceedings·A Osama GaberL W Gaber

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Citations

Apr 8, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Amir A ToorMichael C Neale
Jan 15, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jeremy MeierAmir A Toor
Dec 19, 2014·Frontiers in Immunology·Amir A ToorMichael C Neale
Apr 26, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Yanina PasikhovaAliyah Baluch

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