Anti-thymocyte globulin induced non-cardiogenic pulmonary edema during renal transplantation.

Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
Beena K ParikhVeena R Shah

Abstract

Non-cardiogenic pulmonary edema (NCPE) is a clinical syndrome characterized by simultaneous presence of severe hypoxemia, bilateral alveolar infiltrates on chest radiograph, without evidence of left atrial hypertension/congestive heart failure/fluid overload. The diagnosis of drugrelated NCPE relies upon documented exclusion of other causes of NCPE like gastric aspiration, sepsis, trauma, negative pressure pulmonary edema. We describe a 28year-old, 50 kg male with ASA risk III posted for laparoscopic renal transplantation, who developed NCPE after 4 hours of administration of rabbit anti-human thymocyte immunoglobulin (ATG). He was successfully treated with mechanical ventilatory support and adjuvant therapy. This report emphasizes that this fatal complication may occur with use of ATG.

References

Sep 1, 1987·Chest·D K MurdockR Pifarre
Jun 12, 1999·Respiration; International Review of Thoracic Diseases·N MaillardP Camus
Apr 29, 2009·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Ewan Christopher GoligherJoseph E Brandwein
Oct 1, 2010·Indian Journal of Anaesthesia·Lalit Kumar RaigerVaibhav Bhargava

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Citations

Apr 15, 2017·The American Journal of Case Reports·Kazuhiro TakahashiJason E Denny

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Methods Mentioned

BETA
X-ray

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