Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ Induction

Nutrients
Fabiana M C CarvalhoAna H A Morais

Abstract

: The increasing prevalence of obesity and, consequently, chronic inflammation and its complications has increased the search for new treatment methods. The effect of the purified tamarind seed trypsin inhibitor (TTIp) on metabolic alterations in Wistar rats with obesity and dyslipidemia was evaluated. Three groups of animals with obesity and dyslipidemia were formed, consuming a high glycemic index and glycemic load (HGLI) diet, for 10 days: Obese/HGLI diet; Obese/standard diet; Obese/HGLI diet + TTIp (730 μg/kg); and one eutrophic group of animals was fed a standard diet. Rats were evaluated daily for food intake and weight gain. On the 11th day, animals were anesthetized and sacrificed for blood and visceral adipose tissue collection. TTIp treated animals presented significantly lower food intake than the untreated group (p = 0.0065), TG (76.20 ± 18.73 mg/dL) and VLDL-C (15.24 ± 3.75 mg/dL). Plasma concentrations and TNF-α mRNA expression in visceral adipose tissue also decreased in obese animals treated with TTIp (p < 0.05 and p = 0.025, respectively) with a negative immunostaining. We conclude that TTIp presented anti-TNF-α activity and an improved lipid profile of Wistar rats with dyslipidemia and obesity induced by a hig...Continue Reading

References

Jul 1, 1980·Analytical Biochemistry·B R OakleyN R Morris
Apr 1, 1996·Photochemistry and Photobiology·R D Granstein
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·M D BarrachinaY Taché
Mar 13, 1998·The American Journal of Clinical Nutrition·M B Katan
Jun 4, 1999·Seminars in Cell & Developmental Biology·J K Sethi, G S Hotamisligil
Oct 19, 1999·The Journal of Clinical Investigation·E J ParksM K Hellerstein
Nov 24, 1999·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·T E Graham, K B Adamo
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C A MatsonR C Ritter
May 3, 2001·The American Journal of Clinical Nutrition·B Mittendorfer, L S Sidossis
Oct 5, 2001·The Journal of Nutrition·E J Parks
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 22, 2002·The New England Journal of Medicine·Susan Z Yanovski, Jack A Yanovski
May 23, 2002·The Journal of Biological Chemistry·Angela K Stoeckman, Howard C Towle
May 15, 2003·Endocrinology·Christopher J LyonWilla A Hsueh
Dec 23, 2003·Regulatory Peptides·Guillermo GomezGeorge H Greeley
Apr 6, 2005·Annals of Internal Medicine·Zhaoping LiSally C Morton
Dec 13, 2005·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Angela M Carter
Sep 26, 2006·Nature Reviews. Immunology·Herbert Tilg, Alexander R Moschen
Aug 9, 2007·Arquivos brasileiros de endocrinologia e metabologia·Vladimir TavaresRosario D Crespo Hirata
Nov 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Arti ShahMuredach P Reilly
Feb 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Paska A PermanaPeter D Reaven
Sep 8, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S KomarnytskyI Raskin
Jan 22, 2011·Nature Reviews. Immunology·Noriyuki OuchiKenneth Walsh
May 5, 2011·Autoimmunity Reviews·Fabio CacciapagliaAntonella Afeltra
Jul 14, 2012·Bioscience, Biotechnology, and Biochemistry·Wenya ChenHiroshi Hara
Jul 21, 2012·Nature Immunology·Thirumala-Devi Kanneganti, Vishwa Deep Dixit
Oct 9, 2013·Hormones and Behavior·Frank A DucaMihai Covasa

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
RNA assay

Software Mentioned

Image J
Graph Pad Prism
Graph Pad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.