Anti-TNF-alpha therapy in ankylosing spondylitis

Cytokine
Filip De KeyserHerman Mielants

Abstract

Ankylosing spondylitis (AS) is the prototype disease within the spondyloarthropathies (SpA), a group of diseases presenting mainly with spondylitis, pauci-articular peripheral arthritis and enthesiopathy. Non-steroidal anti-inflammatory drugs (NSAID) are the classical cornerstone of medical therapy in these patients; no real disease modifying antirheumatic treatment was available, until recently. TNF-alpha blocking agents (monoclonal antibodies or soluble receptors) are the first representative drugs, of which the indication has recently been expanded to encompass also patients with AS. Here, we review the data on clinical efficacy and safety, with focus on the compounds infliximab and etanercept. Publication of trial results with adalimumab is still under way; the efficacy of this compound in AS seems comparable with the other two agents.

References

Jan 19, 1999·Rheumatic Diseases Clinics of North America·F De KeyserE M Veys
Dec 22, 1999·Alimentary Pharmacology & Therapeutics·D H Present
Nov 30, 2000·The New England Journal of Medicine·P E LipskyUNKNOWN Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
May 3, 2002·The New England Journal of Medicine·Jennifer D GormanJohn C Davis
Nov 13, 2003·Arthritis and Rheumatism·John C DavisUNKNOWN Enbrel Ankylosing Spondylitis Study Group
Feb 27, 2004·The New England Journal of Medicine·Bruce E SandsSander J van Deventer
Sep 4, 2004·Annals of the Rheumatic Diseases·A CalinS Fatenejad
Feb 5, 2005·Arthritis and Rheumatism·Désirée van der HeijdeUNKNOWN Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group

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Citations

Dec 1, 2010·Rheumatology International·Olga V BritanovaDmitriy M Chudakov
Aug 24, 2006·Current Opinion in Pulmonary Medicine·Francisco P Quismorio
Jun 7, 2007·Current Opinion in Rheumatology·Filip De Keyser
Jul 28, 2007·Clinical Pharmacokinetics·Ulrich KlotzMatthias Schwab
May 13, 2008·Trends in Molecular Medicine·Sonja HermanGeorg Schett
Mar 28, 2008·Journal of Cellular and Molecular Medicine·Anna Franca MiliaMarco Matucci-Cerinic

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