Anti-TNF Levels in Cord Blood at Birth are Associated with Anti-TNF Type

Journal of Crohn's & Colitis
Shannon L KanisC Janneke van der Woude

Abstract

Pregnancy guidelines for women with inflammatory bowel disease [IBD] provide recommendations regarding anti-TNF cessation during pregnancy, in order to limit foetal exposure. Although infliximab [IFX] leads to higher anti-TNF concentrations in cord blood than adalimumab [ADA], the recommendations are similar. We aimed to demonstrate the effect of anti-TNF cessation during pregnancy on foetal exposure, for IFX and ADA separately. We conducted a prospective single-center cohort study. Women with IBD, using IFX or ADA, were followed-up during pregnancy. In case of sustained disease remission, anti-TNF was stopped in the third trimester. At the birth, the anti-TNF concentration was measured in the cord blood. A linear regression model was developed to demonstrate anti-TNF concentration in cord blood at birth. In addition, outcomes such as disease activity, pregnancy outcomes and 1-year health outcomes of infants were collected. We included 131 pregnancies that resulted in a live birth [73 IFX, 58 ADA]. At birth, 94 cord blood samples were obtained [52 IFX, 42 ADA], showing significantly higher levels of IFX than ADA [p < 0.0001]. Anti-TNF type and stop week were used in the linear regression model. During the third trimester, IFX t...Continue Reading

References

Nov 1, 1996·American Journal of Reproductive Immunology : AJRI·A MalekH Schneider
Jul 10, 2003·Vaccine·Neil E Simister
Jan 20, 2004·The Journal of Antimicrobial Chemotherapy·Hanneke B M OttersBart W Koes
Mar 18, 2005·Alimentary Pharmacology & Therapeutics·U MahadevanD G Binion
Apr 21, 2005·BMC Medical Research Methodology·Stela Pudar HozoIztok Hozo
Jun 19, 2007·The American Journal of Gastroenterology·Bente NørgårdKirsten Fonager
Apr 22, 2008·The American Journal of Gastroenterology·Deepa ReddyAsher A Kornbluth
Nov 17, 2009·Early Human Development·Gerard H A VisserJan M Wit
Mar 4, 2011·Alimentary Pharmacology & Therapeutics·Z ZelinkovaC J van der Woude
Aug 11, 2011·Inflammatory Bowel Diseases·Fabian SchnitzlerPaul Rutgeerts
Jan 12, 2012·Clinical & Developmental Immunology·Patricia PalmeiraMagda Carneiro-Sampaio
Jul 21, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ingrid OrdásWilliam J Sandborn
Dec 4, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Uma MahadevanMaria T Abreu
Sep 30, 2014·Alimentary Pharmacology & Therapeutics·M R K L LieC J van der Woude
Oct 1, 2014·Pediatrics·Tamazoust GuiddirLoïc de Pontual
Jan 21, 2015·Journal of Crohn's & Colitis·C J van der WoudeUNKNOWN European Crohn’s and Colitis Organization
Dec 22, 2015·Gastroenterology·Geoffrey C NguyenUNKNOWN Canadian Association of Gastroenterology
Mar 24, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alison de LimaC Janneke van der Woude
Mar 21, 2017·Alimentary Pharmacology & Therapeutics·C H SeowR Panaccione

❮ Previous
Next ❯

Citations

Jun 16, 2018·Journal of Crohn's & Colitis·Cynthia H SeowRemo Panaccione
Jun 14, 2019·Therapeutic Advances in Gastroenterology·Sarah E ShannahanMark A Peppercorn
Dec 19, 2019·Alimentary Pharmacology & Therapeutics·Ailsa Hart
Aug 27, 2019·F1000Research·Mark SamaanSara McCartney
Sep 29, 2020·British Journal of Clinical Pharmacology·Gaby A M EliesenFrans G M Russel
Jan 8, 2021·Expert Opinion on Drug Safety·Robyn LaubeRupert W Leong
Feb 8, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Millie D LongUma Mahadevan
May 4, 2020·Best Practice & Research. Clinical Gastroenterology·Sherman Picardo, Cynthia H Seow
Jul 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Carla CarnovaleIrene Cetin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.