Abstract
Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are common disorders associated with increased rates of cardiovascular disease (CVD), but the contribution of cytokine-induced inflammation to impaired cardiovascular function in these conditions remains poorly understood. We assessed the effect of anti-TNF therapy on myocardial and vascular function, myocardial tissue characteristics and perfusion in inflammatory arthropathy and systemic rheumatic disease (IASRD) patients, using cardiovascular magnetic resonance (CMR). 20 RA patients, 7 AS patients, 5 PsA patients without previously known CVD scheduled to commence anti-TNF therapy and 8 RA patients on standard disease modifying antirheumatic drugs underwent CMR at 1.5 T, including cine, tagging, pulse wave velocity (PWV), T2-weighted, native and postcontrast T1 mapping, ECV quantification, rest and stress perfusion and late gadolinium enhancement (LGE) imaging. Following anti-TNF therapy, there was significant reversal of baseline subclinical cardiovascular dysfunction, as evidenced by improvement in peak systolic circumferential strain (p < 0.001), peak diastolic circumferential strain rate (p < 0.001), and total aortic PWV, (p < 0.001). This...Continue Reading
Citations
May 31, 2019·Current Opinion in Lipidology·Rachel H MackeyLarry W Moreland
Jan 21, 2020·British Journal of Clinical Pharmacology·Laurence KnowlesPhilip J Chowienczyk
Jul 1, 2020·Rheumatology International·George Markousis-MavrogenisSophie I Mavrogeni
Jun 21, 2020·Current Rheumatology Reports·George Markousis-MavrogenisSophie I Mavrogeni
Dec 13, 2018·Clinical Rheumatology·Bożena Targońska-StępniakMaria Majdan
May 8, 2020·Clinical Rheumatology·Jianlong ShuLianjie Shi
Aug 30, 2020·Annals of the Rheumatic Diseases·Sven PleinMaya H Buch
Nov 11, 2020·Rheumatology and Therapy·Paras KarmacharyaMaureen Dubreuil
Dec 22, 2020·Frontiers in Pharmacology·Hongyan QianGuixiu Shi
Jan 8, 2021·Insights Into Imaging·Wojciech TańskiAndrzej Szuba
May 14, 2019·Reumatología clinica·Silvia Esmeralda Pérez-TopeteVerónica González-Díaz
Jan 12, 2021·Saudi Journal of Biological Sciences·Fahad A Al-Abbasi
Jan 28, 2021·Rheumatology·Juliette TennenbaumUNKNOWN Club Rhumatismes et Inflammations (CRI)
Mar 7, 2021·Expert Review of Clinical Immunology·George A KarpouzasSarah R Ormseth
Mar 2, 2021·Toxicology and Applied Pharmacology·Alessandro VenosaAndrew J Gow
Mar 23, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Lei ZhaoXiaohai Ma
Apr 4, 2021·Diagnostics·George Markousis-MavrogenisSophie I Mavrogeni
Apr 17, 2021·Journal of Translational Medicine·David J CoulsonJolanta U Weaver
May 22, 2021·Journal of Inflammation Research·George E FragoulisGeorge D Kitas
Jul 14, 2021·Acta Cardiologica·Faisal MasoodPeter Luzzi