Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases.

International Journal of Cardiology
Ntobeko NtusiTheodoros D Karamitsos

Abstract

Rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are common disorders associated with increased rates of cardiovascular disease (CVD), but the contribution of cytokine-induced inflammation to impaired cardiovascular function in these conditions remains poorly understood. We assessed the effect of anti-TNF therapy on myocardial and vascular function, myocardial tissue characteristics and perfusion in inflammatory arthropathy and systemic rheumatic disease (IASRD) patients, using cardiovascular magnetic resonance (CMR). 20 RA patients, 7 AS patients, 5 PsA patients without previously known CVD scheduled to commence anti-TNF therapy and 8 RA patients on standard disease modifying antirheumatic drugs underwent CMR at 1.5 T, including cine, tagging, pulse wave velocity (PWV), T2-weighted, native and postcontrast T1 mapping, ECV quantification, rest and stress perfusion and late gadolinium enhancement (LGE) imaging. Following anti-TNF therapy, there was significant reversal of baseline subclinical cardiovascular dysfunction, as evidenced by improvement in peak systolic circumferential strain (p < 0.001), peak diastolic circumferential strain rate (p < 0.001), and total aortic PWV, (p < 0.001). This...Continue Reading

Citations

May 31, 2019·Current Opinion in Lipidology·Rachel H MackeyLarry W Moreland
Jan 21, 2020·British Journal of Clinical Pharmacology·Laurence KnowlesPhilip J Chowienczyk
Jul 1, 2020·Rheumatology International·George Markousis-MavrogenisSophie I Mavrogeni
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Jan 12, 2021·Saudi Journal of Biological Sciences·Fahad A Al-Abbasi
Jan 28, 2021·Rheumatology·Juliette TennenbaumUNKNOWN Club Rhumatismes et Inflammations (CRI)
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Mar 23, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Lei ZhaoXiaohai Ma
May 22, 2021·Journal of Inflammation Research·George E FragoulisGeorge D Kitas

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