Anti-TNF Monotherapy for Crohn's Disease: a 13-year Multicentre Experience

Journal of Crohn's & Colitis
L Peyrin-BirouletXavier Roblin

Abstract

Anti-tumour necrosis factor [TNF] therapy in combination with thiopurine is the most effective strategy for Crohn's disease, but raises safety concerns. In a retrospective multicentre study, we investigated long-term outcome of patients starting anti-TNF monotherapy for Crohn's disease and investigated whether introducing an immunomodulator in patients losing response to anti-TNF monotherapy is effective for resetting immunogenicity. A total of 350 adult patients with Crohn's disease received either infliximab [n = 178, 51%] or adalimumab [n = 172, 49%] monotherapy. Mean duration of follow-up was 42 months. An immunomodulator was initiated in 53 patients [15%]. At last follow-up, 73.1% [n = 38] were in clinical remission [one patient with missing data]. Multivariate analysis identified anti-TNF type [higher need for starting immunomodulator for infliximab than for adalimumab; p = 0.0058] and first- vs second-/third-/fourth-line anti-TNF therapy [p = 0.014] as predictors of immunomodulator initiation. Among the 18 patients with available data, introduction of an immunomodulator was able to restore infliximab trough level within the therapeutic range and to induce clinical remission in 10 patients [55%]. Cumulative probability of...Continue Reading

References

Jan 29, 2009·The American Journal of Gastroenterology·Javier P Gisbert, Julián Panés
Oct 29, 2009·The American Journal of Gastroenterology·Laurent Peyrin-BirouletWilliam J Sandborn
Apr 16, 2010·The New England Journal of Medicine·Jean Frédéric ColombelUNKNOWN SONIC Study Group
Mar 17, 2011·The American Journal of Gastroenterology·Vincent BillioudLaurent Peyrin-Biroulet
Jun 8, 2011·Gut·Laurent Peyrin-BirouletUNKNOWN International Programme to Develop New Indexes for Crohn's Disease (IPNIC) group
Dec 6, 2011·Inflammatory Bowel Diseases·Nicolas WillietLaurent Peyrin-Biroulet
Oct 30, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shomron Ben-HorinYehuda Chowers
May 9, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Charlène DuchesneUNKNOWN CREGG (Club de Reflexion des cabinets et Groupes d’Hépato-Gastroentérologie)
Aug 12, 2014·Gastroenterology Clinics of North America·Parambir S DulaiLaurent Peyrin-Biroulet
Apr 12, 2015·Journal of Crohn's & Colitis·Konstantinos PapamichaelGerassimos J Mantzaris

❮ Previous
Next ❯

Citations

Jun 23, 2016·Expert Opinion on Biological Therapy·Lieven PouillonLaurent Peyrin-Biroulet
Dec 15, 2016·Expert Opinion on Biological Therapy·Fabio Salvatore MacalusoMario Cottone
Jan 3, 2018·Journal of Crohn's & Colitis·Tomer GreenerMark S Silverberg
Jan 18, 2018·Digestive Diseases and Sciences·Konstantinos PapamichaelAdam S Cheifetz
Oct 29, 2019·Expert Review of Gastroenterology & Hepatology·James J AshtonR Mark Beattie
Oct 12, 2019·Minerva gastroenterologica e dietologica·Fabio S Macaluso, Ambrogio Orlando
May 31, 2017·Scandinavian Journal of Gastroenterology·Fabio Salvatore MacalusoAmbrogio Orlando
Feb 22, 2017·Inflammatory Bowel Diseases·Laura E TargownikCharles N Bernstein
Apr 13, 2019·Gastroenterology Report·Daniel J WongVitaliy Y Poylin
Mar 21, 2021·European Journal of Gastroenterology & Hepatology·Antonio TursiMarcello Picchio
Aug 14, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Francesca PenaginiGian Vincenzo Zuccotti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.