Anti-trypanosomal activity of (8-hydroxymethylen)-trieicosanyl acetate against infective forms of Trypanosoma cruzi

Pharmaceutical Biology
Matilde Jimenez-CoelloMaria Salud Perez Gutierrez

Abstract

The activity of an (8-hydroxymethylen)-trieicosanyl acetate compound obtained from chloroform extracts of Senna villosa (Mill.) H.S. Irwin & Barneby (Leguminosae) against Trypanosoma cruzi was evaluated in vivo. Oral doses of 2.1, 8.4, and 33.6 microg/g were tested for 28 days in BALB/c mice infected with T. cruzi. Reduced parasitemia levels of 70.5%, 73.8%, and 80.9%, respectively, were observed. A significant reduction in amastigote nests was detected in the cardiac tissue of treated animals at doses of 8.4 and 33.6 microg/g. The LD50 of (8-hydroxymethylen)-trieicosanyl acetate was impossible to determine because none of the animals died, even at oral doses of 5000 microg/g; consequently, it was impossible to determine the acute oral toxicity in vivo.

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Citations

Jan 1, 2011·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Matilde Jimenez-CoelloKarla Yolanda Acosta-Viana
Jan 1, 2011·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Matilde Jiménez-CoelloEugenia del S Guzmán-Marín
Jul 17, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana del Carmen Susunaga-NotarioFrancisco Javier Alarcón-Aguilar
Dec 24, 2019·Journal of Applied Toxicology : JAT·Paritosh Mondal, Ansuman Chattopadhyay
Apr 10, 2021·Journal of Experimental Pharmacology·Ana Lia MazzetiVanessa Carla Furtado Mosqueira

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