Anti-tuberculosis drug therapy in mice of different inbred strains

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Boris V NikonenkoCarol A Nacy

Abstract

Standard anti-tuberculosis (TB) drug therapy had distinct effects on the bacilli burden in mice of DBA/2, C3H, SWR/J, and C57BL/6 inbred strains. To standardize the TB infection process, susceptible DBA/2 mice were infected with 1/10 of the dose used for relatively resistant C57BL/6 mice, such that the lung CFUs were roughly identical 3 weeks after infection when therapy was initiated. We found that TB treatment was more effective in the susceptible DBA/2 mice than in the relatively resistant C57BL/6 mice.

References

Aug 27, 1998·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G Govoni, P Gros
Jun 3, 1999·The Journal of Infectious Diseases·C LavebrattE Schurr
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·I KramnikB R Bloom
Sep 7, 2001·Annual Review of Microbiology·L G Wayne, C D Sohaskey
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Anne J M LenaertsIan M Orme
May 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Loukia-Maria MitsosPhilippe Gros
Aug 23, 2003·Infection and Immunity·Oliver C TurnerIan M Orme
Apr 9, 2005·Nature·Hui PanIgor Kramnik
Aug 5, 2008·Recent Patents on Anti-infective Drug Discovery·Boris V NikonenkoCarol A Nacy

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