PMID: 9542597May 30, 1998Paper

Anti-tubulin antibodies in a sensorimotor neuropathy patient alter tubulin polymerization

Acta Neuropathologica
E B StubbsG J Siegel

Abstract

The effect of anti-tubulin antibodies present in the serum of a patient with a progressive sensorimotor neuropathy on microtubule assembly was examined. The patient's serum was reactive on immunoblots with a single band of proteins of 55-kDa from homogenates of neural tissues. Tubulin was identified as the quantitatively major component of these 55-kDa proteins. Polymerization of tubulin in vitro was significantly enhanced by the patient's serum. A monoclonal antibody to nerve-specific class III beta-tubulin precisely duplicated the immunoreactive profile of the patient's serum, while an antibody to class (I + II) beta-tubulins also reacted with tubulins in non-neural tissues. The results indicate for the first time that human antisera reactive with nerve specific beta-tubulin can alter tubulin polymerization-depolymerization dynamics.

Citations

Dec 22, 2009·Integrative Biology : Quantitative Biosciences From Nano to Macro·Bénédicte CauweGhislain Opdenakker
Nov 1, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J SvarcováI Malbohan
Apr 7, 2007·Journal of Neuropathology and Experimental Neurology·Ruth HuizingaSandra Amor
Jul 16, 2016·Mediators of Inflammation·Elisa GarciaAntonio Ibarra
Jul 9, 1999·Muscle & Nerve·R H Quarles, M D Weiss
Feb 24, 2006·Microbiology and Immunology·Yasuhiko TanakaTomohiro Kato

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