Anti-tumor activity of a polysaccharide from blueberry

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiyun SunXianjun Meng

Abstract

Blueberries (Vaccinium spp.) are rich in bioactive compounds. However, the biological activity of polysaccharides from blueberry has not been reported so far. This study evaluated the anti-tumor and immunological activities of a polysaccharide (BBP3-1) from blueberry in S180-bearing mice. The experimental results indicated that BBP3-1 (100 mg·kg-1·d-1) inhibited the tumor growth rate by 73.4%. Moreover, this group, compared with the model control, had shown an effect of increasing both the spleen and thymus indices (p < 0.05), increasing phagocytosis by macrophages (p < 0.05), boosting the proliferation and transformation of lymphocytes (p < 0.01), promoting the secretion of TNF-α, IFN-γ, and IL-2 (p < 0.05) and improving NK cell activity (p < 0.01). From this study, we could easily conclude that BBP3-1 has the ability to inhibit tumor progression and could act as a good immunomodulator.

References

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Citations

Jul 16, 2016·Journal of the Science of Food and Agriculture·Daheng ZhengXiangyang Wu
Oct 31, 2018·Critical Reviews in Food Science and Nutrition·Sara SilvaManuela Pintado
Jun 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kaiwei HuangChengfeng Wu
Sep 19, 2018·International Journal of Molecular Sciences·Luyao MaJiazhen Yang
Sep 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fei ChenYoulong Cao
Aug 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaoya ShangWeining Niu
Dec 8, 2020·Food Science & Nutrition·Yi-Yang YuJian-Hua Guo

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Methods Mentioned

BETA
ELISA
PMФ
Assay

Software Mentioned

SPSS

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