Anti-tumor activity of cytokines against opportunistic vascular tumors in mice

International Journal of Cancer. Journal International Du Cancer
Q G DongF Bussolino

Abstract

Polyoma middle T (PmT)-transformed endothelial cells may represent a unique murine model for human opportunistic vascular tumors. The present study was designed to evaluate the anti-tumor potential of a panel of 13 cytokines against murine PmT-transformed endothelial cells. Interferon gamma (IFNgamma) and transforming growth factor beta 1 (TGFbeta1) substantially decreased in a dose-dependent manner the proliferation of a panel of 6 PmT-transformed cell lines. IFNalpha and tumor necrosis factor alpha(TNFalpha) had marginal anti-proliferative activity, whereas other molecules (interleukins-1, -2, -4, -6 and -13, IFNbeta, leukemia inhibitory factor, oncostatin M, granulocyte-macrophage colony-stimulating factor) caused no growth inhibition. IFNgamma and TGFbeta1 were therefore selected for further analysis of their mechanism of action and in vivo relevance. IFNgamma and TGFbeta1 reduced the activity of phosphatidylinositol-3-kinase and the production of phosphatidylinositol 3,4-biphosphate, without modifying the tyrosine kinase(s) activity associated with PmT. IFNgamma and TGFbeta1 were also tested for their ability to modify the in vivo growth of the PmT-transformed endothelial cells H5V in syngeneic C57B1/6 mice. Treatment with...Continue Reading

References

May 28, 1992·The New England Journal of Medicine·R A EzekowitzJ Folkman
May 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A MantovaniE Dejana
Jan 1, 1991·Annual Review of Physiology·M Klagsbrun, P A D'Amore
Apr 1, 1987·Journal of Virology·B S SchaffhausenT M Roberts
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M StreuliC Weissmann
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·K S CampbellD C Pallas
Jun 23, 1993·Annals of the New York Academy of Sciences·F RuscettiJ Ortaldo
Jan 21, 1993·Nature·X Van OstadeW Fiers

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Citations

Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M StraslyF Bussolino
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M AreseF Bussolino
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Justin SausvilleRicardo A Feldman
Aug 24, 2001·Developmental Biology·S Zhao, P A Overbeek

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