PMID: 16520662Mar 8, 2006Paper

Anti-tumor activity of Titanocene Y in xenografted Caki-1 tumors in mice

Anti-cancer Drugs
Iduna FichtnerMatthias Tacke

Abstract

The benzyl-substituted unbridged titanocene bis-[(p-methoxybenzyl)cyclopentadienyl] titanium(IV) dichloride (Titanocene Y) was tested in vitro against human renal cancer cells (Caki-1), in which it showed an IC50 value of 36 x 10 mol/l. Titanocene Y was then given in vivo in doses of 10, 20, 30, 40 and 50 mg/kg on 5 consecutive days to Caki-1-bearing mice, and it showed concentration-dependent and statistically significant tumor growth reduction with respect to a solvent-treated control cohort. The maximum tolerable dose of Titanocene Y was determined to be 40 mg/kg and it showed significantly better tumor volume growth reduction than cisplatin given at a dose of 2 mg/kg. This superior activity of Titanocene Y with respect to cisplatin will hopefully lead to clinical tests against metastatic renal cell cancer in the near future.

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Citations

Nov 15, 2011·Chemical Reviews·Katherine M Buettner, Ann M Valentine
May 24, 2008·Chemical Society Reviews·Katja Strohfeldt, Matthias Tacke
Feb 16, 2008·Metal-based Drugs·Megan HoganMatthias Tacke
Aug 1, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Clara PampillónMatthias Tacke
Jan 7, 2011·Metallomics : Integrated Biometal Science·Susan W SarsamKimberly A Watson
Jun 15, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Li Ming GaoEnrique Meléndez
Feb 22, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Ramón HernándezEnrique Meléndez
Dec 31, 2015·Journal of Inorganic Biochemistry·Isabel de la Cueva-AliqueEva Royo
Dec 29, 2009·Journal of Inorganic Biochemistry·Andrea ErxlebenMatthias Tacke
Nov 6, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Holger WeberMatthias Tacke
Jan 11, 2008·ChemMedChem·James ClaffeyMatthias Tacke
Aug 21, 2008·Chemistry, an Asian Journal·Anna F A Peacock, Peter J Sadler
Jan 26, 2016·Metallomics : Integrated Biometal Science·Melchior CiniTracey D Bradshaw
May 24, 2016·Chemical Science·Jacob Fernández-GallardoMaría Contel
Oct 12, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·L KaterA Prokop
Nov 26, 2010·European Journal of Medicinal Chemistry·Mariagrazia NapoliPasquale Longo
Feb 7, 2017·Metallomics : Integrated Biometal Science·Sergio A Loza-RosasArthur D Tinoco
Apr 7, 2007·European Journal of Medicinal Chemistry·Clara PampillónMatthias Tacke
Feb 1, 2007·Anti-cancer Drugs·Olaf OberschmidtMatthias Tacke
May 14, 2017·Journal of the American Society for Mass Spectrometry·Rahel P EberleStefan Schürch
Nov 17, 2010·Journal of Medicinal Chemistry·Gilles GasserNils Metzler-Nolte

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