Anti-tumor and anti-angiogenic effects of Phyllanthus urinaria in mice bearing Lewis lung carcinoma

International Immunopharmacology
Sheng-Teng HuangJong-Hwei S Pang

Abstract

Phyllanthus urinaria, a widely used herb medicine in Asia, was tested for its anti-tumor effect in vivo for the first time. The anti-tumor activity in P. urinaria extract was evaluated by its effect on tumor developed in C57BL/6J mice with implantation of Lewis lung carcinoma cells. The oral administration of P. urinaria to mice caused significant inhibition of tumor development with lower occurrence rate and markedly reduced tumor size. Neither the total body weight of mouse nor the weights of organs including heart, lung, liver, spleen and kidney revealed any difference between two groups, suggesting limited in vivo cytotoxic effect of P. urinaria in mice. TUNEL assay demonstrated the increase of apoptosis in tumor sections prepared from P. urinaria-treated mice compared with control mice. It is worth of note that the neovascularization in tumor was inhibited in P. urinaria-treated mice, which implicated the potential anti-angiogenic effect of P. urinaria. Further study using an in vitro matrix-induced tube formation of HUVECs again confirmed the anti-angiogenic action of P. urinaria. P. urinaria exerted no inhibitory effect on the growth of HUVECs, however, the migration of HUVECs as analyzed using transwell assay was suppre...Continue Reading

References

Nov 1, 1990·Journal of Natural Products·G R PettitJ A Saenz-Renauld
Jan 1, 1997·Annual Review of Nutrition·M S Kurzer, X Xu
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshijiH Fukui
Jan 8, 2000·The Journal of Biological Chemistry·G D KamphausR Kalluri
Feb 13, 2001·Cardiovascular Research·D EnglishD N Brindley
Mar 30, 2001·The Journal of Biological Chemistry·Y MaeshimaR Kalluri
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Frank K ReiherSteven C Campbell
Apr 24, 2003·Medicinal Research Reviews·Wenying RenLi Zhang

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Citations

Jul 25, 2012·Clinical Reviews in Allergy & Immunology·Hong-Di MaZhe-Xiong Lian
Dec 17, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Sheng-Teng HuangJong-Hwei S Pang
Oct 8, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Hua-Yew ChengChun-Ching Lin
Aug 1, 2010·Therapeutic Delivery·Doreen PonMoses Sing Sum Chow
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Hsin-Yi WuSheng-Teng Huang
Nov 2, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Swati PundGanesh Rasve
Dec 4, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ko-Hsiu LuYih-Shou Hsieh
Jan 6, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Sujatha RamasamySugumaran Manickam
May 23, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shyr-Yi LinWen-Chi Hou
Sep 20, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Kun-Chun ChiangJong-Hwei S Pang
Jun 28, 2012·Journal of Ethnopharmacology·Suphattra SangmaleeSuchada Sukrong
Jul 31, 2007·Phytotherapy Research : PTR·Chien-Min YangChun-Ching Lin
May 24, 2008·The Journal of Pharmacy and Pharmacology·Abhinav AgarwalNarendra K Jain
Oct 18, 2018·Frontiers in Pharmacology·Madamanchi Geethangili, Shih-Torng Ding

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