Anti-tumor effect of ultrasound-induced Nordy-loaded microbubbles destruction

Journal of Drug Targeting
Xing HuaQinghai Chen

Abstract

Synthesized dl-Nordihydroguaiaretic acid (dl-NGDA or "Nordy") can inhibit the growth of malignant human tumors, especially the tumor angiogenesis. However, its liposoluble nature limits its in vivo efficacy in the hydrosoluble circulation of human. We tried to use the ultrasonic microbubble as the carrier and the ultrasound-induced destruction for the targeted release of Nordy and evaluate its in vitro and in vivo anti-tumor effect. Nordy-loaded lipid microbubbles were prepared by mechanical vibration. Effects of ultrasound-induced Nordy-loaded microbubbles destruction on proliferation of human umbilical vein endothelial cells (HUVECs), tumor derived endothelial cells (Td-ECs), and rabbit transplanted VX2 tumor models were evaluated. The ultrasound-induced Nordy-loaded microbubbles destruction inhibited the proliferations of HUVECs and Td-ECs in vitro, and inhibited the tumor growth and the microvasculature in vivo. Its efficacy was higher than those of Nordy used only and Nordy with ultrasound exposure. Ultrasonic microbubbles can be used as the carrier of Nordy and achieve its targeted release with improved anti-tumor efficacy in the condition of ultrasound-induced microbubbles destruction.

References

Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Apr 27, 2002·European Journal of Radiology·Evan C UngerRachel Quigley
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chih-Chuan ChangRu Chih C Huang
Dec 8, 2005·International Immunopharmacology·Xiu-wu BianJi Ming Wang
Apr 3, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C MöbiusH Witzigmann
Nov 4, 2008·Journal of Pharmaceutical Sciences·Steliyan TinkovConrad Coester
May 30, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Natalya Y RapoportKweon-Ho Nam
May 13, 2010·European Journal of Nuclear Medicine and Molecular Imaging·J R Eisenbrey, F Forsberg
Jan 11, 2011·World Journal of Gastroenterology : WJG·Michiel Postema, Odd Helge Gilja
May 26, 2011·International Journal of Pharmaceutics·Michael C CochranMargaret A Wheatley
Jun 30, 2011·AIDS Patient Care and STDs·Lisa B Hightow-WeidmanUNKNOWN YMSM of Color SPNS Initiative Study Group
Feb 23, 2012·Current Pharmaceutical Design·Nicolas A GeisRaffi Bekeredjian
Jan 16, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bart GeersIne Lentacker
Apr 10, 2013·Gene·Anthony DelalandeChantal Pichon
Mar 29, 2014·Advanced Drug Delivery Reviews·Klazina KooimanNico de Jong
May 27, 2014·Therapeutic Delivery·Zhenzhen FanCheri X Deng
Jul 2, 2014·Molecular Pharmaceutics·Frank KuoElaine M Jagoda
Sep 10, 2014·Journal of Drug Targeting·Tejinder SinghRavindra K Rawal
Sep 30, 2014·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Ilya SkachkovKlazina Kooiman
Dec 3, 2014·Colloids and Surfaces. B, Biointerfaces·Ghaleb A HusseiniAna M Martins
Jul 15, 2015·Ultrasonics·N Wallace, S P Wrenn
Oct 22, 2015·Advances in Experimental Medicine and Biology·Ayache BouakazAlexander A Doinikov
Oct 22, 2015·Advances in Experimental Medicine and Biology·Jason Castle, Steven B Feinstein

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