Anti-tumor effectiveness of electrochemotherapy with bleomycin is increased by TNF-alpha on SA-1 tumors in mice

Cancer Letters
G SersaD Miklavcic

Abstract

With the aim to increase anti-tumor effectiveness of electrochemotherapy, adjuvant immunotherapy with tumor necrosis factor-alpha (TNF-alpha) was tested on tumors in mice. Increased anti-tumor effectiveness on SA-1 tumors was observed after combining TNF-alpha, injected either intratumorally or peritumorally, with electrochemotherapy using suboptimal dose of bleomycin (BLM). The increased anti-tumor effectiveness was neither the result of potentiated anti-tumor effectiveness of TNF-alpha due to exposure of tumors to electric pulses, nor due to interaction with BLM. Therefore, the effect of adjuvant TNF-alpha treatment might be immunomodulatory, augmenting the anti-tumor activity of electrochemotherapy, and possibly adding a systemic component to the localized electrochemotherapy treatment.

References

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·L M Mir, S Orlowski
Jan 18, 2012·Current Opinion in Oncology·Alessandro TestoriGiulio Tosti
Jun 10, 2008·Journal of Veterinary Internal Medicine·M CemazarJ Teissie
Mar 14, 2014·Biomedical Engineering Online·Damijan MiklavčičGregor Serša
Jun 7, 2014·Annual Review of Biomedical Engineering·Martin L YarmushDamijan Miklavčič
Mar 20, 2016·Cancer Metastasis Reviews·Christophe Y Calvet, Lluis M Mir
Jun 13, 2015·Cancer Immunology, Immunotherapy : CII·Gregor SersaDamijan Miklavcic
Jun 1, 2000·International Journal of Oral and Maxillofacial Surgery·S OmuraK Fujita
Jul 7, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G SersaM Snoj
Mar 25, 2018·Basic & Clinical Pharmacology & Toxicology·Ales GroseljGregor Sersa
Apr 14, 2016·Radiology and Oncology·Andrejc HribernikMarko Snoj
Dec 12, 2018·Oncology Research and Treatment·Mateusz WichtowskiWojciech Witkiewicz
May 18, 2010·Expert Review of Anticancer Therapy·Tomaz JarmGregor Sersa
Mar 29, 2014·Journal of Surgical Oncology·Luca G CampanaCarlo Riccardo Rossi
Aug 22, 2018·Oncology Letters·Armando De VirgilioAntonio Greco
May 16, 2020·Electromagnetic Biology and Medicine·Mahsa MansourianZuhair Mohammad Hassan
Nov 10, 2009·Expert Review of Anticancer Therapy·Mecker G MöllerGerald C O'Sullivan
Feb 16, 2016·Radiology and Oncology·Andrejc HribernikMarko Snoj

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