Anti-tumor effects and cellular mechanisms of resveratrol

Drug Discoveries & Therapeutics
Guohua HanNorihiro Kokudo

Abstract

Resveratrol (3, 5, 4'-trihydroxystilbene) is a phytoalexin contained in a variety of plants, such as grapes, berries and especially in the dried roots of Polygonum cuspidatum Sieb. et Zucc. It has been shown to exhibit anti-oxidative and anti-inflammation activity, and to reverse the effects of aging. Its ability to suppress cell proliferation, induce apoptosis and suppress the metastasis and invasion in a number of cell lines has prompted a large interest from people for its use as an anti-tumor component. In this review, evidence of resveratrol's anti-tumor effects and molecular mechanisms are recapitulated. First, we present the anti-apoptosis, anti-invasion/metastasis and anti-inflammation effect of resveratrol; second, the main signaling pathways involved in these activities are described and summarized with the studies of different tumors involved. Resveratrol not only induces apoptosis of tumor cells through intrinsic/extrinsic pathways and cell cycle arrest, but also inhibits the invasion and metastasis abilities of tumors via modulating collagen degradation-related molecular targets. Altogether, the present findings suggest the anti-tumor potential of resveratrol against various types of cancers.

References

Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·B D GehmJ L Jameson
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R NelsonL M Matrisian
Jun 1, 2002·Science·Harald Wajant
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman
Jun 27, 2006·Journal of Cellular and Molecular Medicine·D C JingaCristiana Matache
Oct 24, 2006·Cell·William Y Kim, Norman E Sharpless
Jan 4, 2007·The Journal of Pathology·C Papazoglu, A A Mills
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Jan 19, 2008·Nature Reviews. Cancer·Anthony G Letai
Apr 17, 2008·Nature Reviews. Molecular Cell Biology·Alexei Degterev, Junying Yuan
May 20, 2008·Mutation Research·Joydeb Kumar Kundu, Young-Joon Surh
Jan 22, 2009·Analytica Chimica Acta·Laurent CamontDominique Bonnefont-Rousselot
Mar 12, 2009·Current Opinion in Lipidology·Carles Cantó, Johan Auwerx
Jun 10, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lonnie D WilliamsJochen Bausch
Feb 6, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Palak ParekhK V K Rao
Feb 20, 2010·PloS One·Hiyaa Singhee GhoshPaul D Robbins
May 11, 2010·Archives of Biochemistry and Biophysics·Sangwoon ChungIrfan Rahman
Dec 8, 2010·Experimental Cell Research·Paola AllavenaAlberto Mantovani
Jan 26, 2011·Annals of the New York Academy of Sciences·Yogeshwer Shukla, Richa Singh
Jan 26, 2011·Annals of the New York Academy of Sciences·Thomas SzekeresWalter Jäger
May 10, 2011·Cell Communication and Signaling : CCS·Shahedur Rahman, Rezuanul Islam
Jul 9, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Francesca De AmicisSebastiano Andò
Jan 6, 2012·International Journal of Oncology·Hisanori MikiAiro Tsubura
Feb 14, 2012·Bioorganic & Medicinal Chemistry Letters·Guanghui WangXinsheng Yao
Apr 3, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M Emília JuanJoana M Planas
Jun 16, 2012·Journal of Andrology·Kazuhiro IguchiKazuyuki Hirano

❮ Previous
Next ❯

Citations

Sep 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea MattareiCristina Paradisi
Mar 8, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Allan LançonNorbert Latruffe
Mar 17, 2016·Drug Discovery Today·Milla KibbleTero Aittokallio
Jan 20, 2016·Antioxidants·Kyriazoula ChatzianagnostouCristina Vassalle
Oct 30, 2016·Frontiers in Cardiovascular Medicine·Christoph KoentgesHeiko Bugger
Mar 10, 2017·Drug Development and Industrial Pharmacy·Valentina Trotta, Santo Scalia
Nov 7, 2017·Nutrients·Guilherme Felipe Santos FernandesJean Leandro Dos Santos
Sep 30, 2017·Experimental & Molecular Medicine·Jyun-Pei JhouShiang-Jong Tzeng
Jul 30, 2019·Drug Development and Industrial Pharmacy·Heba F SalemDemiana M Naguib
Mar 18, 2020·International Journal of Molecular Sciences·Maura CalvaniClaudio Favre
Feb 3, 2016·Pain·Eva KosekA Kathleen Sluka
Dec 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Xinnan WuQing Ji
Apr 11, 2019·Combinatorial Chemistry & High Throughput Screening·Ritu Kataria, Anurag Khatkar
Apr 21, 2020·Oxidative Medicine and Cellular Longevity·Farzaneh ShakeriAmirhossein Sahebkar
May 4, 2017·Gastroenterology Research and Practice·Alexandra WagnerovaRoman Gardlik
Aug 9, 2016·Medicina·Lolita KuršvietienėJurga Bernatonienė
Apr 13, 2018·Oxidative Medicine and Cellular Longevity·Wei SunBin Liu
Oct 7, 2020·Critical Reviews in Food Science and Nutrition·Liyi WangTizhong Shan
Dec 22, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh YarmohammadiGholamreza Karimi
Dec 23, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Damian GarbiczHanna Krawczyk
Feb 25, 2021·Journal of Food Biochemistry·Dhvani SharmaVasanti Suvarna
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristian HernándezWilson Cardona-G
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nicola MicaleAntonio Speciale
May 27, 2020·Journal of the American Chemical Society·Xiaofan JiaT Brent Gunnoe
Dec 15, 2016·Journal of Agricultural and Food Chemistry·Haili WuZhuoyu Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.