PMID: 6819080Jan 1, 1982

Anti-tumor effects of an antiserum raised in syngeneic mice to a tumor-specific T suppressor factor

Cancer Immunology, Immunotherapy : CII
T Maier, J G Levy

Abstract

DBA/2 mice inoculated with either cells from the syngeneic P815 tumor or tumor cell membrane extracts develop T suppressor cells which suppress the in vitro generation of cytotoxic T lymphocytes with specificity for the tumor. A soluble suppressor factor with similar properties can be isolated from suppressor cell-enriched populations. It can be highly purified by appropriate immunoadsorption. Antisera to this suppressor factor raised in either DBA/2 or C57BL/6 mice can specifically absorb out suppressor factor and eliminate suppressor cells in the presence of complement. The in vivo effects of these antisera were tested for their ability to modulate the growth of P815 tumors in DBA/2 mice. It was found that the antiserum raised in syngeneic (DBA/2) but not allogeneic (C57BL/6) mice was able to significantly slow the rate of tumor growth and to prolong survival in treated mice. The antiserum was effective in this way only if it was administered early in the course of tumor growth. It was shown that this effect was not attributable to the presence in the serum of antibodies directed to antigens present on P815 cells, and it therefore appears to be due to interference with the function of T suppressor cells arising early in the i...Continue Reading

Related Concepts

Immune Sera
Therapeutic Immunosuppression
Immunotherapy
Leukemia L1210
Mice, Inbred C57BL
Mice, Inbred DBA
Neoplasms, Experimental
Mast-Cell Sarcoma
T-Lymphocyte

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