Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma.

International Journal of Nanomedicine
Jian-Min QinHe-Bai Shen

Abstract

Hepatocellular carcinoma is difficult to diagnose early, and most patients are already in the late stages of the disease when they are admitted to hospital. The total 5-year survival rate is less than 5%. Recent studies have showed that brucine has a good anti-tumor effect, but high toxicity, poor water solubility, short half-life, narrow therapeutic window, and a toxic dose that is close to the therapeutic dose, which all limit its clinical application. This study evaluated the effects of brucine immuno-nanoparticles (BIN) on hepatocellular carcinoma. Anionic polymerization, chemical modification technology, and phacoemulsification technology were used to prepare a carboxylated polyethylene glycol-polylactic acid copolymer carrier material. Chemical coupling technology was utilized to develop antihuman AFP McAb-polyethylene glycol-polylactic acid copolymer BIN. The size, shape, zeta potential, drug loading, encapsulation efficiency, and release of these immune-nanoparticles were studied in vitro. The targeting, and growth, invasion, and metastasis inhibitory effects of this treatment on liver cancer SMMC-7721 cells were tested. BIN were of uniform size with an average particle size of 249 ± 77 nm and zeta potential of -18.7 ± ...Continue Reading

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Citations

Mar 17, 2016·Analytical Cellular Pathology (Amsterdam)·Mei LinTing Guo
Apr 23, 2013·Drug Development and Industrial Pharmacy·Jun ChenBao-chang Cai
Jul 22, 2018·Toxicology Mechanisms and Methods·Uma SaminathanRajendran Jayaganesh
Dec 5, 2019·Organic & Biomolecular Chemistry·Chandrashekar Mudithanapelli, Mi-Hyun Kim
Jul 2, 2019·Experimental and Therapeutic Medicine·Min TangCheng-Song He
Apr 21, 2020·Frontiers in Pharmacology·Lu LuXin Luan
Jun 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhe MaZhidong Liu
Apr 10, 2021·International Journal of Biological Macromolecules·Jixian ZhangHonglei Tian
Aug 30, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Keenan J Mintz, Roger M Leblanc

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Methods Mentioned

BETA
surgical resection
chemical modification
dynamic light scattering

Software Mentioned

SPSS

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