Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells

International Journal of Molecular Sciences
Kathleen MikkelsenVasso Apostolopoulos

Abstract

Chronic inflammation can lead to tumour initiation and progression. Vitamin B complex has the ability to regulate the immune response and, therefore, inflammation but many of the mechanistic and molecular processes involved in this regulation are still not fully understood. This study sought to determine some of these processes by studying the effects of vitamin B2 (riboflavin) B6 (pyridoxine) and B9 (folic acid) on un-differentiated pro-monocytic lymphoma cells in regard to their ability to alter the proliferation, migration, apoptosis, cytokines and expression levels of programmed death ligand 1. We show that vitamin B2, B6 and B9, on pro-monocytic lymphoma cells exerted an anti-tumorigenic effect. This data could form the basis for future studies in using vitamin B supplementation to reduce cancer cell growth in vivo.

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Citations

Sep 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Evelyn PeñalozaRafael Garrett
Sep 10, 2020·International Journal of Molecular Sciences·Jeannie DevereauxVasso Apostolopoulos
Oct 13, 2020·Pharmacology & Therapeutics·Laura MasuelliRoberto Bei
Nov 8, 2020·Nutrients·Christine Tara PetersonScott N Peterson
May 1, 2021·Nutrients·Amna Al MansooriLily Stojanovska

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
flow cytometry
Assay
FACS
cytokine

Clinical Trials Mentioned

NCT02923921

Software Mentioned

Image J
ARMO
GraphPad Prism TM
Excel
Prism excel Pad

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