PMID: 6978293Mar 15, 1982Paper

Anti-tumor immunity in B-lymphocyte-deprived mice. III. Immunity to primary Moloney sarcoma virus-induced tumors

International Journal of Cancer. Journal International Du Cancer
J GordonM Feldman

Abstract

Tumor induction and immunity to tumors were studied following the injection of Moloney sarcoma virus (MSV) into mice whose B-lymphocyte functions had been suppressed by the chronic administration of anti-IgM antibodies. Two preparations of MSV were used; one which gives rise to tumors which uniformly regress in normal adult mice, and another which elicits progressively growing tumors in the majority of recipients. The tumor incidence, mean tumor size, and tempo of regression were not modified by treatment with anti-IgM. However, whereas tumors induced by the regressor virus were all rejected in 19 NRG-treated and 29 untreated recipients, continued growth was obtained in 2 of 23 B-lymphocyte-deprived mice. Furthermore, in 9 additional mice from this group, apparent rejection was followed by tumor recurrence at the site of the initial tumor. Continued growth was accompanied by widespread metastasis. These tumors were freely transplantable to normal syngeneic recipients. Metastasis and transplantability were also detected in 7 of 24 anti-IgM-treated mice given progressor virus, but were not seen in the control animals. Recurrence and metastasis was obtained despite the presence of high levels of specific cytotoxic T lymphocytes in...Continue Reading

References

Jan 1, 1977·Advances in Cancer Research·J P Levy, J C Leclerc
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Apr 15, 1980·International Journal of Cancer. Journal International Du Cancer·S Becker, S Haskill

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Citations

Jul 16, 2010·Immunology and Cell Biology·Connie JackamanDelia Jane Nelson
Jul 28, 2011·International Journal of Cancer. Journal International Du Cancer·Seong-A JuByung-Sam Kim
Jul 19, 2012·International Reviews of Immunology·Andrea KhongBruce W S Robinson
Jun 15, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacquelyn M LykkenThomas F Tedder
Mar 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·David J DiLilloThomas F Tedder

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