Anti-tumor potential of astragalus polysaccharides on breast cancer cell line mediated by macrophage activation

Materials Science & Engineering. C, Materials for Biological Applications
Wenfang LiTianqing Liu

Abstract

Adverse effects are pressing challenges produced by chemotherapy and radiotherapy for the treatment of breast cancer. Nontoxic herbal medicines are therefore considered as a favorable alternative. Astragalus membranaceus has attracted growing interest in the field of biomedicine thanks to its various biological activities, among which the anticancer activity is considered to be closely associated with its active component-astragalus polysaccharide (APS). Currently, direct anti-tumor activity and the activation of immune response of the host have been widely acknowledged as the mechanism by which APS exerts its anti-cancer activity. In this study, we aimed to investigate whether APS could inhibit the growth of MCF-7 cells and activate macrophages to further kill cancer cells. The results indicated that the obtained APS was a pyran-type polysaccharide, containing 89.75% total carbohydrate and a minor amount of uronic acid (9.3%). Although APS did not significantly inhibit the growth of MCF-7 cells growth, encouragingly, APS-activated RAW264.7 macrophages present anti-cancer activity as evidenced by (a) cell proliferation inhibition (with an inhibitory rate of 41%), (b) G1-phase cell cycle arrest, as well as (c) the regulation of ...Continue Reading

Citations

Oct 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ke LiYuguang Du
Mar 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Le FengDihua Shangguan
Jun 17, 2020·Frontiers in Pharmacology·Qing-Xia GanQin-Wan Huang
Apr 9, 2020·Frontiers in Pharmacology·Yijun ZhengYongqi Liu
Jun 20, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S ShamsaeiO Raiesi
Apr 25, 2020·Journal of Ethnopharmacology·Zhejie ChenYitao Wang
Aug 17, 2021·Chemical Biology & Drug Design·Zhongqing WangQing Lin
Sep 5, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Aliya SheikYun Suk Huh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.