Anti-tumor promoting action of phthalic acid mono-n-butyl ester cupric salt, a biomimetic superoxide dismutase

Carcinogenesis
S YamamotoR Kato

Abstract

Skin tumor promotion induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) was inhibited by a concurrent and topical application of phthalic acid mono-n-butyl ester cupric salt (PAMBCu) in CD-1 mice initiated with 7,12-dimethylbenz[a]anthracene. PAMBCu inhibited TPA-caused epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. skin inflammation. However, neither PAMBCu nor superoxide dismutase (SOD) inhibited TPA-caused ODC induction in primary cultured mouse epidermal cells. 7-Bromomethylbenz[a]anthracene (BrMBA) is known to be a non-TPA type of tumor promoting agent. Epidermal ODC induction and inflammation caused by BrMBA were not inhibited by a concurrent application of PAMBCu. When mice were topically treated twice with PAMBCu, i.e. concurrently with and 7 h after BrMBA treatment, BrMBA-caused ODC induction was markedly suppressed. The same dose regimen of PAMBCu, however, failed to inhibit tumor promotion and inflammation caused by BrMBA. PAMBCu showed SOD-mimetic activity in superoxide generating systems, i.e. xanthine-xanthine oxidase reaction and TPA-stimulated polymorphonuclear leukocytes (PMN). Mono-n-butyl phthalate, which lacks SOD-mimetic activity, failed to inhibit TPA-caused ODC inductio...Continue Reading

Citations

Apr 1, 2010·Pharmaceutical Research·Joydeb Kumar Kundu, Young-Joon Surh
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Mohammad T M Al-DajaniHoong-Kun Fun
Jul 23, 1999·Annals of the New York Academy of Sciences·C BarandierJ De Leiris
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Mohammad T M Al-DajaniHoong-Kun Fun
Oct 16, 2014·BMC Complementary and Alternative Medicine·Ahmed M Aboul-EneinHany A El-Shemy

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