PMID: 26320438Sep 1, 2015Paper

Anti Tumoral Properties of Punica Granatum (Pomegranate) Peel Extract on Different Human Cancer Cells

Asian Pacific Journal of Cancer Prevention : APJCP
Sina ModaeinamaRana Jahanban-Esfahlan

Abstract

Medicinal plants, especially examples rich in polyphenolic compounds, have been suggested to be chemopreventive on account of antioxidative properties. Punica granatum (PG) (pomegranate) is a well known fruit in this context, but its cytotoxicity in cancer cells has not been extensively studied. Here, we investigated the antiproliferative properties of a peel extract of PG from Iran in different human cancer cells. A methanolic extract of pomegranate peel (PPE) was prepared. Total phenolic content(TPC) and total flavonoid conetnt (TFC) were determined by colorimetric assays. Antioxidant activity was determined by DPPH radical scavenging activity. The cytotoxicity of different doses of PPE (0, 5, 20, 100, 250, 500, 1000 μg/ml) was evaluated by MTT assays with A549 (lung non small cell cancer), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer), and PC-3 (prostate adenocarcinoma) cells. Significant (P<0.01) or very significant (P<0.0001) differences were observed in comparison with negative controls at all tested doses (5-1000 μg/ml). In all studied cancer cells, PPE reduced the cell viability to values below 40%, even at the lowest doses. In all cases, IC50 was determined at doses below 5μg/ml. In this regard, MCF-7 breast ad...Continue Reading

References

Jan 5, 2002·Journal of Agricultural and Food Chemistry·R P SinghG K Jayaprakasha
Dec 13, 2006·Journal of Ethnopharmacology·Ephraim P Lansky, Robert A Newman
Jul 7, 2007·Seminars in Cancer Biology·Deeba N SyedHasan Mukhtar
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Mehran Mesgari AbbasiRana Jahanban- Esfahlan
Oct 24, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Mehran Mesgari AbbasiRana Jahanban-Esfahlan

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Citations

Jan 27, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pooja SharmaFarrukh Afaq
Jul 13, 2019·Current Pharmaceutical Design·Vesna VučićAleksandra Arsić
Apr 5, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Khaled SeidiMehran Mesgari Abbasi
Aug 26, 2020·Anatomy & Cell Biology·Kamonwan JongsomchaiSugunya Mahatheeranont

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