Anti-tumour necrosis factor treatment increases circulating T helper type 17 cells similarly in different types of inflammatory arthritis

Clinical and Experimental Immunology
D N HullPeter C Taylor

Abstract

We investigated changes in circulating T helper type 17 (Th17) cells following anti-tumour necrosis factor (TNF) in rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients. Peripheral blood mononuclear cells (PBMC) were isolated from 25 RA, 15 AS and eight PsA patients at baseline 4 and 12 weeks after treatment, and Th17 cell frequencies were analysed using interleukin (IL)-17 enzyme-linked immunospot (ELISPOT) and flow cytometry. A significant increase in IL-17-producing cells was observed by ELISPOT in RA and AS patients at 12 weeks. Flow cytometry confirmed significant increases in CD4(+) IL-17(+) cells at 12 weeks in RA and AS and 4 weeks in PsA patients. Anti-TNF treatment increases circulating Th17 cells in three different diseases.

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Citations

Nov 2, 2015·Rheumatology International·Maurizio RossiniDavide Gatti
Apr 26, 2017·Cytokine·Eugene Y Kim, Kamal D Moudgil
Dec 7, 2017·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Sonja DulicAttila Balog
Mar 16, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Keiichi KoizumiKanji Sugita
Apr 2, 2019·Frontiers in Immunology·Laura MaggiLorenzo Cosmi
Sep 13, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Thomas AndersenBent Winding Deleuran
Apr 6, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Sonja DulicAttila Balog
Jul 7, 2021·Nature Reviews. Rheumatology·Benoit L Salomon

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