PMID: 8583384Sep 1, 1995Paper

Anti-ulcer activity of higher primary alcohols of beeswax

The Journal of Pharmacy and Pharmacology
D CarbajalR Mas

Abstract

The anti-ulcer effects of a natural mixture of higher aliphatic primary alcohols, designated D-002, isolated from beeswax, were compared with those of cimetidine on indomethacin-, ethanol-, water-immersion-induced ulcers and on gastric secretion in rats. D-002 (25-50 mg kg-1 p.o.) was similar to cimetidine in dose-dependently reducing the duration of indomethacin-induced ulcers while also being effective in preventing ethanol-induced ulcers, which are not affected by cimetidine. On the other hand, D-002 (100 mg kg-1) moderately decreased the volume of gastric basal secretion in pylorus-ligated rats, but not the acidity. Nevertheless, it inhibited gastric ulcer induced by pylorus-ligation at doses (50 mg kg-1) that were ineffective in decreasing the volume. In addition, 100 mg kg-1 of D-002 prevented the formation of acute gastric ulcers induced in rats by water-immersion stress. The results demonstrate the anti-ulcer activity of the preparation in different experimental models suggesting its potential value for ulcer therapy.

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Citations

Jan 25, 2011·Journal of Natural Medicines·Yazmin RaveloRosa Más
Oct 2, 2001·Archives of Medical Research·R MenéndezS Jiménez
Feb 20, 2003·Nutrition·Johanna C TaylorG Brian Lockwood
Mar 18, 2003·Journal of Medicinal Food·Vivian MolinaRosa Más
Apr 29, 2005·Journal of Medicinal Food·Vivian MolinaRosa Más
Mar 4, 2014·World Journal of Gastroenterology : WJG·Zullyt ZamoraAmbar Oyarzabal
May 23, 1998·Drug and Chemical Toxicology·I RodeiroM Garcia
May 27, 2015·Indian Journal of Pharmaceutical Sciences·Vivian MolinaD Carbajal
Mar 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M NoaS Valdés
Mar 13, 2012·International Journal of Molecular Sciences·Anderson Marques de OliveiraEmiliano Barreto
Mar 22, 2014·The Korean Journal of Internal Medicine·Roberto PuentePablo Reyes
Aug 23, 2017·Scientific Reports·Mahesh K KaushikYoshihiro Urade
Aug 1, 1996·The Journal of Pharmacy and Pharmacology·D CarbajalJ Magraner
Sep 17, 2016·Asian Pacific Journal of Tropical Medicine·Filippo FratiniAntonio Felicioli
Jun 19, 2001·Journal of Applied Toxicology : JAT·C AlemánR Más
Sep 16, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·D CarbajalR Más

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