Anti-VEGF molecular targeted therapies in common solid malignancies: comprehensive update for radiologists

Radiographics : a Review Publication of the Radiological Society of North America, Inc
Sree Harsha TirumaniNikhil H Ramaiya

Abstract

Angiogenesis is an essential component of the growth and dissemination of solid malignancies and is mediated by several proangiogenic factors. The most widely studied proangiogenic factor is vascular endothelial growth factor (VEGF). A major class of molecular targeted therapies (MTTs) inhibit the VEGF axis and are referred to as antiangiogenic MTTs. There are two main types of anti-VEGF MTTs: drugs targeting circulating VEGF and drugs interfering with the activity of the VEGF receptors. The cancers against which antiangiogenic MTTs have had the greatest effect are gliomas, non-small cell lung cancer, colorectal cancer, hepatocellular carcinoma, renal cell carcinoma, and gastrointestinal stromal tumor. These cancers respond to antiangiogenic MTTs in a different way than they respond to conventional chemotherapy. Instead of the traditional Response Evaluation Criteria in Solid Tumors (RECIST), each of these cancers therefore requires its own individualized treatment response criteria (TRC). Examples of individualized TRC include the Response Assessment in Neuro-oncology (RANO) criteria for gliomas, modified RECIST for hepatocellular carcinoma, and Morphology, Attenuation, Size, and Structure (MASS) criteria for renal cell carcin...Continue Reading

References

Jul 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D R MacdonaldJ G Cairncross
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Jan 1, 1981·Cancer·A B MillerA Winkler
Oct 3, 2002·Nature Reviews. Cancer·Robert Kerbel, Judah Folkman
Oct 22, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A R Padhani
Jan 8, 2003·Seminars in Oncology·Judah Folkman
Apr 25, 2003·The British Journal of Radiology·K A Miles, M R Griffiths
Aug 13, 2003·Respiratory Care Clinics of North America·Mark A Socinski
Feb 3, 2005·Journal of the National Cancer Institute·Janet C MillerJames H Thrall
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fairooz F KabbinavarSomnath Sarkar
Apr 25, 2006·Nature Reviews. Molecular Cell Biology·Anna-Karin OlssonLena Claesson-Welsh
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark A Rosen, Mitchell D Schnall
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vicki L GoodmanRichard Pazdur
Mar 21, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Young-Jae ChoHenri G Colt
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert S BenjaminChuslip Charnsangavej
Aug 10, 2007·Journal of the National Cancer Institute·Frank A ScappaticciHerbert Hurwitz
Feb 28, 2008·Current Opinion in Oncology·Martin Gutierrez, Giuseppe Giaccone
Apr 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Edith M MaromAmir Onn
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cedric de BazelaireNeil M Rofsky
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Simon J CrabbScott A Laurie
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry S FriedmanTimothy Cloughesy
Feb 23, 2010·Seminars in Liver Disease·Riccardo Lencioni, Josep M Llovet
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Toni K ChoueiriJoaquim Bellmunt
Apr 20, 2010·International Journal of Radiation Oncology, Biology, Physics·Victor A LevinEdward F Jackson
Jul 6, 2010·International Journal of Clinical Oncology·Tadaaki YamadaSeiji Yano
Nov 26, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ho Yun LeeMyung Jin Chung
Jan 15, 2011·Current Neurology and Neuroscience Reports·Whitney B PopeBenjamin M Ellingson

❮ Previous
Next ❯

Citations

Sep 29, 2015·Expert Review of Gastroenterology & Hepatology·António P MatosRichard C Semelka
Sep 13, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Tatiana KelilSree Harsha Tirumani
Aug 18, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Andrew J MartinUNKNOWN INTEGRATE I investigators
Jul 12, 2018·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Julie C BirchJohn R Leyendecker
Jul 12, 2018·AJR. American Journal of Roentgenology·Ailbhe C O'NeillNikhil H Ramaiya
Jan 11, 2020·Frontiers in Physiology·Jacopo SabbatinelliAngelica Giuliani
Jan 18, 2017·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Katherine M KrajewskiAtul B Shinagare
Aug 24, 2017·Journal of Thoracic Imaging·Girish S ShroffMylene T Truong
Oct 6, 2018·Abdominal Radiology·Colin MarshallFrancesco Alessandrino
Jun 11, 2021·ACS Applied Materials & Interfaces·Yunseo HwangDongwon Yoo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Current Opinion in Oncology
Martin Gutierrez, Giuseppe Giaccone
Current Oncology Reports
Suzanne R HaymanVesna D Garovic
Nature Reviews. Neurology
Andrew D NordenPatrick Y Wen
© 2021 Meta ULC. All rights reserved