Anti-VEGF therapy for diabetic macular edema. From theory to clinical practice

Vestnik oftalmologii
A Zh FursovaO G Gusarevich

Abstract

To evaluate clinical effectiveness of aflibercept therapy for patients with diabetic macular edema (DME) - both naïve to the drug and unresponsive to previous anti-VEGF treatment. The study included 127 patients (127 eyes) divided into two groups. The first group consisted of 100 primary DME patients (100 eyes) with mean age of 68.48±2.56 years and average disease duration of 12.50±7.85 years. The second group comprised 27 patients (27 eyes) with resistant macular edema who had received three or more 0.5 mg ranibizumab loading injections. Their average age was 66±4.12 and the mean number of previous anti-VEGF injections before changing therapy was 4.56±1.21. The evaluation parameters included Best Corrected Visual Acuity (BCVA) and Central Retinal Thickness (CRT) that were assessed initially and after each 2 mg aflibercept injection (at 1-month intervals during the 6 months of DME therapy). The average number of aflibercept injections in the first group was 4.34±1.22. BCVA improved in 100% of patients of that group after the 3rd injection with resulting mean value of 0.32±0.15. Maximum BCVA improvement was seen after the 6th injection amounting to 0.46±0.2. CRT decreased in 100% of patients of that group after the 1st injection...Continue Reading

References

Dec 6, 2011·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkTrexler M Topping
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
Feb 15, 2012·Ophthalmology·Quan Dong NguyenUNKNOWN RISE and RIDE Research Group
Sep 12, 2012·Archives of Ophthalmology·Susan B BresslerUNKNOWN Diabetic Retinopathy Clinical Research Network
Nov 26, 2013·American Journal of Ophthalmology·Paul MitchellUNKNOWN Diabetic Macular Edema Treatment Guideline Working Group
Jul 12, 2014·Ophthalmology·Jean-François KorobelnikDavid M Brown
Feb 19, 2015·The New England Journal of Medicine·UNKNOWN Diabetic Retinopathy Clinical Research NetworkRoy W Beck
Oct 9, 2015·Investigative Ophthalmology & Visual Science·Kyle KovacsJorge G Arroyo
Jan 10, 2016·JAMA Ophthalmology·Susan B BresslerUNKNOWN Diabetic Retinopathy Clinical Research Network
Jan 10, 2016·American Journal of Ophthalmology·Ehsan RahimyJason Hsu
Apr 20, 2017·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Ursula Schmidt-ErfurthAnat Loewenstein

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