Anti VEGF Therapy Under Real-Life Conditions: Adherance Determines Long Term Outcome in Neovascular AMD

Klinische Monatsblätter für Augenheilkunde
H G Sachs, R G H Wilke

Abstract

Data from real-life studies on neovascular AMD (nvAMD) generally fall significantly behind respective data from interventional prospective trials. This can be attributed at least partially to differences in patient cohorts concerning both stages of AMD (including consecutive scarring or atrophy), as well as adherence to therapy. We have been interested in the question which of the two factors most affects outcome in a real-life setting. Retrospective study of 1500 cases of nvAMD over a time period of up to 5 years. Inclusion of all cases treated for nvAMD which received at least 3 intravitreal injections, no exclusion of cases. Treatment was according to pro re nata (PRN) scheme. In total, results for gain in visual acuity (letter score + 1,4 and - 0,8 for year 1 and 2, respectively), and number of injections (5,2 and 3,3) are well comparable to data from other German real-life studies. The variance within the dataset, however, is relatively large. Definition of one subgroup characterized by significantly better baseline visual acuity and significantly higher number of injections demonstrates expectedly significantly better outcome. This better performance, however, is outranged by a subgroup defined only by its significantly h...Continue Reading

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Katharina M DroegeSascha Fauser
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Armin Wolf, Anselm Kampik
Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Katharina M DroegeS Fauser
© 2022 Meta ULC. All rights reserved