Anti-viral antibodies in HIV (HTLV-III) infection possess auto-antibody activity against a CH1 domain determinant in human IgG: possible immunological consequences.

Immunology Letters
B SölderD R Stanworth

Abstract

Two regions of the envelope glycoprotein gp120 of the human immunodeficiency virus were shown to have a significant degree of homology to human immunoglobulin-gamma heavy-chain constant domains. We have now synthesized three short linear peptides, the first representing a sequence within the CH1 domain, the second an analogue of it, and the third representative of a region within the viral gp120. Polyclonal antibodies against these peptides were raised in rabbits and used to demonstrate that they all reacted well with human native IgG. Vice-versa, we observed the reaction of these antisera to the virus in an ELISA system. The proportion of sera reacting with the human gamma-chain peptide was significantly higher in HIV-positive individuals than in HIV-negative individuals, suggesting production of anti-viral antibodies in AIDS patients with auto-antibody activity against a CH1 domain determinant in human IgG.

Citations

Jan 1, 1992·International Journal of Clinical & Laboratory Research·A Amadori, L Chieco-Bianchi
May 11, 1991·Immunology Letters·R L Bjork
Jan 1, 1992·Vox Sanguinis·C SüsalG Opelz
Mar 1, 1997·Journal of Clinical Pathology·S YamanoI Saito
Dec 1, 1996·Genitourinary Medicine·T T NgW J Morrow
Sep 17, 2004·International Reviews of Immunology·Veljko VeljkovicRadmila Metlas
Sep 17, 2004·International Reviews of Immunology·Radmila Metlas, Veljko Veljkovic

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