Anti-Warburg effect of rosmarinic acid via miR-155 in colorectal carcinoma cells

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Yichun XuJianwen Liu

Abstract

The Warburg effect, glycolytic production of ATP under aerobic conditions, is found to be a universal feature of most cancer cells. Our study was aimed to determine whether rosmarinic acid (RA) had the anti-Warburg effect activity against colorectal carcinoma. Furthermore, the mechanism for the anti-Warburg effect by RA would be investigated. In our study, we found that RA suppressed glucose consumption and lactate generation in colorectal carcinoma cells; meanwhile, RA inhibited the expression of transcription factor hypoxia-inducible factor-1α (HIF-1α) that affects the glycolytic pathway. Chronic inflammation is a key promoting factor of the Warburg effect. As we supposed, the present study also showed that RA could not only repress proinflammatory cytokines using enzyme-linked immunosorbent assay but it could also suppress microRNAs related to inflammation by real-time PCR. Therefore, we proposed that RA may inhibit the Warburg effect by suppressing the inflammatory response of colorectal carcinoma cells. Recent studies have provided evidence that miR-155 was an important mediator between inflammation and carcinogenesis. We further showed that miR-155 acted to repress the Warburg effect through the mechanism of inactivating ...Continue Reading

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G L Wang, G L Semenza
Mar 6, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·U M Moll, L M Schramm
Jun 3, 1999·Biochemical Pharmacology·A SahuM K Pangburn
May 15, 2002·Current Biology : CB·Mariana Lagos-QuintanaThomas Tuschl
Dec 17, 2002·Phytochemistry·Maike Petersen, Monique S J Simmonds
Mar 29, 2003·Physiological Reviews·Marc Mareel, Ancy Leroy
Feb 24, 1956·Science·O WARBURG
Dec 31, 2003·Biochemical and Biophysical Research Communications·Xin Lin Zu, Michael Guppy
Feb 8, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Olga J G SchiepersMichael Maes
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Oct 18, 2008·Mutation Research·Michelle Andrade FurtadoDenise Crispim Tavares
Dec 31, 2008·Seminars in Cancer Biology·Gregg L Semenza
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bharat B AggarwalBokyung Sung
Oct 24, 2009·Nature Reviews. Cancer·Hua YuRichard Jove
Nov 7, 2009·The American Journal of Pathology·Tsuyoshi HamaguchiMasahito Yamada
Feb 17, 2010·Planta medica·Yichun XuJianwen Liu
Feb 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Motonobu SaitoCurtis C Harris
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Sep 14, 2011·International Journal of Cancer. Journal International Du Cancer·Jianqiang LiuXiangyu Kong
Oct 21, 2011·Nucleic Acids Research·Mark D Halling-BrownBissan Al-Lazikani
Nov 1, 2011·Chinese Journal of Cancer·Hui LingGeorge A Calin
Jan 13, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Karthikkumar VenkatachalamNalini Namasivayam
Dec 4, 2012·Cell Reports·Thomas B HuffakerRyan M O'Connell
Apr 4, 2013·The American Journal of Chinese Medicine·Su-Jin KimSeung-Heon Hong
Apr 23, 2013·The Journal of Pharmacy and Pharmacology·Ruzena SotnikovaPeter Krenek
May 11, 2013·International Journal of Cancer. Journal International Du Cancer·Roger A VaughanKristina A Trujillo
May 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruozhen HuRyan M O'Connell
Dec 7, 2013·The Journal of Investigative Dermatology·Laura Y McGirtChristine M Eischen
Dec 7, 2013·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Laleh HajhosseiniNava Ainehchi
Feb 21, 2014·Seminars in Immunology·Koji Taniguchi, Michael Karin

❮ Previous
Next ❯

Citations

Jan 27, 2018·Journal of Translational Medicine·Ajaikumar B KunnumakkaraBharat B Aggarwal
Aug 24, 2016·Frontiers in Physiology·Fredy O Beltrán-AnayaSandra L Romero-Cordoba
Aug 2, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Francesc Xavier Avilés-JuradoXimena Terra
Jul 20, 2018·Applied Microbiology and Biotechnology·Mallappa Kumara SwamyAli Ghasemzadeh
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen YuJi-Feng Feng
Jun 17, 2021·Journal of Agricultural and Food Chemistry·Asifa KhanMohammad Askandar Iqbal
Jul 3, 2021·International Journal of Molecular Sciences·Aldona Kasprzak
Jul 25, 2021·Cancers·Assunta SellittoRoberta Tarallo
Sep 20, 2018·Journal of Agricultural and Food Chemistry·Angela R GuerraIola F Duarte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.