Anti-Wrinkling and Anti-Melanogenic Effect of Pradosia mutisii Methanol Extract

International Journal of Molecular Sciences
Laura Rojas LorzJae Youl Cho

Abstract

Ultraviolet (UV) exposure causes skin photoaging leading to skin wrinkling and sagging via production of reactive oxygen species (ROS). For this reason, protection from photoaging is an important feature in cosmeceutical and dermatological products. Natural product-derived biomaterials are highly desired as future possible ingredients, because these biomaterials are often safe and effective. In this study, we aimed to characterize the skin protective activity of Pradosia mutisii, traditionally used to treat sunburn and erythema. We determined the free radical scavenging, anti-melanogenic, and moisturizing effects of a methanol extract of Pradosia mutisii (Pm-ME) in keratinocytes (HaCaT cells), melanocytes (B16F10 cells), and fibroblasts (human dermal fibroblasts (HDFs)) at non-cytotoxic concentrations. Pradosia mutisii methanol extract contains coumaric acid as a major component, and the extract exhibited protective activity against UVB- and H₂O₂-induced cytotoxicity. This extract also suppressed the expression of metalloproteinases (MMPs) and cyclooxygenase (COX)-2 in HaCaT cells. A reduction of Sirt-1 expression under UVB- and H₂O₂-treated conditions was recovered in HaCaT cells by Pm-ME. This extract displayed significant fr...Continue Reading

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Citations

Mar 4, 2020·International Journal of Molecular Sciences·Hye Yeon LimJae Youl Cho
Jun 6, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huan LiuLi Lin
Jul 2, 2020·Journal of Medicinal Food·Young-Ran SongTae-Gyu Lim
Dec 22, 2019·International Journal of Molecular Sciences·Sekyoo JeongHyun Jung Kim
Jul 25, 2021·International Journal of Molecular Sciences·Hye Yeon LimJae Youl Cho

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Methods Mentioned

BETA
PCR
Transfection
Assay
electrophoresis

Software Mentioned

NIH imaging
SPSS
Lab Solutions

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