Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with gastric adenocarcinoma

Journal of the Neurological Sciences
B MeglicA Grad

Abstract

Paraneoplastic cerebellar degeneration (PCD) with anti-Yo antibodies is almost always associated with ovarian and breast cancer. We describe a man with anti-Yo-positive PCD and gastric adenocarcinoma. The tumor cells were labeled with anti-Yo antibodies by immunohistochemistry. High serum titers of anti-Yo antibodies were found before surgery and decreased 6 months after resection of the tumor. The expression of Yo antigens by the tumor and the decrease in anti-Yo antibody titers after its removal suggest that the immune response against the Purkinje cells of the cerebellum was triggered by the tumor.

References

Jun 1, 1995·Neurology·O FelicianJ Y Delattre
Feb 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·K TanakaS Tsuji
Jun 3, 1998·AJR. American Journal of Roentgenology·C Chartrand-LefebvreC Beigelman

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Citations

Oct 22, 2003·Progress in Neurobiology·Justyna R Sarna, Richard Hawkes
Apr 19, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P Krolak-SalmonA Vighetto
Dec 4, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M TschernatschF Blaes
Mar 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·K-D ChoiP S Smitt
Dec 26, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·J MatschkeE Köfüncü
May 19, 2010·The Oncologist·Myrna R Rosenfeld, Josep Dalmau
Oct 30, 2013·Case Reports in Neurological Medicine·Linda HasadsriMingtao Wang
Sep 23, 2014·Current Problems in Cancer·Samuel MartelGiovanna Speranza
Oct 1, 2012·Clinical Journal of Gastroenterology·Takashi TaketaHisashi Onodera
Aug 24, 2013·Journal of Clinical Anesthesia·Višnja Nesek AdamAna Markić
Nov 9, 2010·Revue neurologique·G Demarquay, J Honnorat
May 3, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H S KimJ L Conklin
Nov 13, 2007·Neuropathology and Applied Neurobiology·F Aboul-EneinW Kristoferitsch
Oct 3, 2006·Journal of the Neurological Sciences·John E Greenlee
Sep 9, 2016·Annals of Clinical and Translational Neurology·Anand Venkatraman, Puneet Opal
Jan 24, 2020·Case Reports in Oncological Medicine·Tamer OthmanPhyllis Kim
Oct 9, 2020·Journal of Clinical Neurology·Xuan SunZhenfu Wang
Dec 14, 2011·Clinical Nuclear Medicine·Akiyuki MatsuhisaHitoshi Shibuya

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