PMID: 10334423May 20, 1999Paper

Antiadrenergic effect of chronic amiodarone therapy in human heart failure

Journal of the American College of Cardiology
D M KayeM D Esler

Abstract

The aim of the present study was to evaluate the influence of amiodarone on neurochemical parameters of sympathetic nervous activity in patients with congestive heart failure. Unlike most antiarrhythmic agents, amiodarone has been shown to exert a beneficial effect on survival in some studies of patients with congestive heart failure. The pharmacology of this agent is complex, and as such, the mode of its action is unclear in humans. Some experimental studies suggest that amiodarone exerts a sympatholytic effect. To evaluate the effect of amiodarone on sympathetic nervous activity, we measured the total systemic and cardiac norepinephrine (NE) spillover rate by isotope dilution in 58 patients with severe heart failure (left ventricular ejection fraction 20 +/- 1%), 22 of whom were receiving chronic amiodarone treatment. Release rates for dihydroxyphenylalanine (DOPA, a precursor of NE), and endogenous and radiolabeled dihydroxyphenylglycol (DHPG and 3H-DHPG, intraneuronal metabolites of NE and 3H-NE, respectively) were also determined to assess sympathetic neuronal integrity. Amiodarone-treated patients had significantly lower cardiac spillover rates for NE (42%, p = 0.001), DOPA (74%, p < 0.001), DHPG (44%, p < 0.01) and 3H-DH...Continue Reading

References

Aug 1, 1992·Journal of Laparoendoscopic Surgery·V J Bagnato
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Oct 1, 1989·American Heart Journal·W H LeungC Wang
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Nov 1, 1995·Journal of the American College of Cardiology·D M KayeM D Esler

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Citations

Feb 5, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matthew Jason Zimmerman, Myron C Gerson
Aug 15, 2003·Current Problems in Cardiology·Audrey H Wu, Robert J Cody
May 28, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Katsuya TakemuraKunio Miyatake
Feb 18, 2010·Pediatrics International : Official Journal of the Japan Pediatric Society·Etsuko TsudaAya Miyazaki
Jun 26, 2010·Pharmacotherapy·Edward C LiBrian F McBride
Sep 25, 2003·Journal of Cardiovascular Pharmacology and Therapeutics·Daniel C ChooJ Thomas Heywood
Apr 30, 2003·Journal of Cardiovascular Pharmacology·Deepak HaikerwalAnthony M Dart
Aug 2, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·S DingG T Wetzel

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