PMID: 11315361Apr 24, 2001Paper

Antiaggregant and anticoagulant therapy in systemic lupus erythematosus and Hughes' syndrome

Lupus
G Ruiz-IrastorzaG R Hughes

Abstract

Antiaggregant and anticoagulant drugs are essential in the management of the manifestations due to antiphospholipid syndrome (APS) in patients with primary Hughes' syndrome or systemic lupus erythematosus. Coumadin derivatives (warfarin and acenocumarol), heparin and aspirin are used for secondary thromboprophylaxis and treatment of recurrent miscarriage. The available evidence for each indication is reviewed in this paper. There is still debate regarding the optimal intensity of oral anticoagulation, the best drug combination for pregnancy failure in APS and the management of asymptomatic patients with antiphospholipid antibodies.

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Citations

Jul 10, 2003·Autoimmunity Reviews·Guillermo Ruiz-IrastorzaGraham R V Hughes
Oct 18, 2001·Current Opinion in Rheumatology·T LeeC Sandborg
Apr 19, 2002·Paediatric Drugs·Luis CarreñoIndalecio Monteagudo
Sep 10, 2002·Current Rheumatology Reports·Ana I Quintero-Del-Rio
Mar 17, 2009·Expert Opinion on Pharmacotherapy·Gerard Espinosa, Ricard Cervera
Sep 9, 2010·Lancet·Guillermo Ruiz-IrastorzaMunther A Khamashta
Dec 27, 2007·Yonsei Medical Journal·Penka A Atanassova
Jan 12, 2016·Indian Dermatology Online Journal·Aditya Kumar Bubna
Oct 27, 2001·Lupus·G Ruiz-IrastorzaG R Hughes
Apr 21, 2005·Rheumatology·G Ruiz-Irastorza, M A Khamashta
May 1, 2010·Auto- Immunity Highlights·Gerard Espinosa, Ricard Cervera

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Related Concepts

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.