PMID: 8581783Sep 1, 1995Paper

Antiaging action of caloric restriction: endocrine and metabolic aspects

Obesity Research
E J Masoro

Abstract

Restricting the energy intake of mice and rats slows the rate of actuarial aging, delays or prevents most age-associated disease processes, and maintains physiological processes in a youthful state at advanced ages. This manipulation is effective when initiated in young animals or in adult life. Although body fat is decreased by this reduction in energy intake, the reduction in body fat is not causally related to the antiaging action. Nor does this reduction in energy intake slow the aging processes by decreasing the metabolic rate, but it may do so by altering the characteristics of fuel use. Another possible mechanism underlying the antiaging action is the general protection restriction of energy intake provides against harmful agents, an action which may be the result of an alteration in adrenal glucocorticoid physiology.

References

Nov 1, 1992·Journal of Gerontology·E J MasoroC A McMahan
Jun 1, 1990·Journal of Hypertension·P Ferrari, P Weidmann
Jun 1, 1990·Diabetes Care·L RossettiR A DeFronzo
Jun 1, 1990·Diabetes Care·R W Stout
Mar 1, 1989·Diabetes/metabolism Reviews·A H Kissebah, A N Peiris
Mar 1, 1989·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G M ReavenY D Chen
Nov 1, 1986·Biological Reviews of the Cambridge Philosophical Society·A M Holehan, B J Merry
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D E HarrisonC M Astle
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E J MasoroH A Bertrand
May 1, 1993·Molecular and Cellular Biology·A R HeydariA Richardson
Sep 1, 1993·Journal of the American Geriatrics Society·E J Masoro

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Citations

Jan 12, 1999·Mechanisms of Ageing and Development·R WalterF Sierra
Apr 18, 2003·Medical Hypotheses·Victor E Archer
Nov 21, 2000·Free Radical Biology & Medicine·J J RamseyR Weindruch
Oct 19, 2007·Nucleic Acids Research·Ahmad R HeydariArlan Richardson
Jun 29, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D B AllisonD E Harrison
Apr 13, 2000·Connective Tissue Research·C FornieriI P Ronchetti
May 17, 2005·Mechanisms of Ageing and Development·David A Sinclair
May 13, 2005·Mechanisms of Ageing and Development·Colin SelmanJohn R Speakman
May 7, 2002·Journal of the American Veterinary Medical Association·Richard D KealyHoward D Stowe
Nov 9, 2010·Oncogene·A Martín-MontalvoR de Cabo
May 1, 1997·The American Journal of Physiology·J J RamseyJ W Kemnitz

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